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Mus musculus

ABSTRACT: Genome-wide maps of transcription factor and co-factor binding and nucleosome density during B-cell to Macrophage lineage switching

PROVIDER: PRJNA289711 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2125700.fastq.gz	Fastqsanger.gz
	SRR2125710.fastq.gz	Fastqsanger.gz
	SRR2125720.fastq.gz	Fastqsanger.gz
	SRR2125701.fastq.gz	Fastqsanger.gz
	SRR2125711.fastq.gz	Fastqsanger.gz

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Project description:Genome-wide maps of transcription factor and co-factor binding during B-cell to Macrophage lineage switching

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Genome-wide maps of transcription factor and co-factor binding during B-cell to Macrophage lineage switching

Project description:Using homogenous populations of cells undergoing cell switching we observed an interplay between lymphoid and myeloid transcription factors during lineage switching Examination of transcription factors genome-wide binding profiles several time points after induction of B-cell to macrophage lineage switching

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Nucleosome binding by the pioneer transcription factor OCT4

Project description:The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription factor that plays a role in stem cell pluripotency. In the present study, we biochemically analyzed the nucleosome binding by OCT4. Crosslinking mass spectrometry showed that OCT4 binds the nucleosome.

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ena-DATASET-MGH2-10-11-2015-05:01:11:768-248 - samples

Project description:Whole genome sequences of ACC primagrafts, Histone modification maps and transcription factor binding maps for ACC primagrafts and primary tumors. Processed ChIP-seq data is available on GEO under accession number GSE76465.

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