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Mus musculus

ABSTRACT: Histone arginine methyltransferase CARM1 Is Crucial for Epigenetic Regulation of Starvation-induced Autophagy

PROVIDER: PRJNA295297 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2340500_1.fastq.gz	Fastqsanger.gz
	SRR2340500_2.fastq.gz	Fastqsanger.gz
	SRR2340501.fastq.gz	Fastqsanger.gz
	SRR2340502.fastq.gz	Fastqsanger.gz
	SRR2340493_1.fastq.gz	Fastqsanger.gz

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Histone arginine methyltransferase CARM1 Is Crucial for Epigenetic Regulation of Starvation-induced Autophagy

Project description:Autophagy is a highly conserved self-digestion process, essential to maintain homeostasis and viability in response to nutrient starvation. Although the components of autophagy in the cytoplasm have been well-studied, molecular basis for the epigenetic regulation of autophagy is poorly understood. Here, we identify histone arginine methyltransferase CARM1 as a critical component of autophagy. We found that nutrient starvation increased CARM1 protein level and subsequently histone H3R17 dimethylation. Genome-wide analyses reveal that CARM1 exerts transcriptional coactivator function on autophagy-related genes and lysosomal genes through TFEB. Our findings demonstrate a previously unrecognized role of CARM1-dependent histone arginine methylation as a critical nuclear event of autophagy.

2016-06-17 | GSE72901 | GEO

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (RNA-Seq)

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (RNA-Seq)

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ATAC-Seq)

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ATAC-Seq)

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ChIP-Seq)

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ChIP-Seq)

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Expression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls

Project description:Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their littermates, fail to breath, and die shortly after birth, demonstrating the critical role of CARM1 in development.We performed gene expression analysis to identify genes that are responsible for hyperproliferaion in CARM1 knockout lung. RNA extracted from murine lung at E18.5 with carm1 knockouts and wild type controls was hybridised to Affymetrix mouse430.2 GeneChips to identify differentially expressed genes in the disease state.

2010-07-07 | E-GEOD-21606 | biostudies-arrayexpress

Histone Demethylase KDM3A Functions As an Essential Factor for Epigenetic Control of Autophagy

Project description:Autophagy phenomenon is an essential mechanism to regulate cell homeostasis and is activated by various stresses such as nutrient starvation. It is well known that when autophagy is activated and how important components in the cytoplasm cause a series of reactions, but the regulatory mechanism of transcription in the nucleus is poorly known. Here, we identify that histone demethylase KDM3A plays a crucial role in the transcription of autophagy and lysosomal genes. Notably, KDM3A is increased in transcriptional levels in both glucose and amino acid starvation. Especially, transcriptional increase of histone demethylase in response to glucose starvation is dependent on AMP-activated protein kinase (AMPK). Furthermore, genome-wide analysis reveals that KDM3A acts as a co-activator in the expression of autophagy and lysosomal genes. Our finding of histone demethylase signaling cascade in nucleus, modulating histone demethylation signature is one of the predominant epigenetic event in autophagy activation, thereby providing the functional and mechanistic link between epigenetic control and transcriptional regulation of autophagy upon nutrient starvation.

2020-08-30 | GSE103573 | GEO

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 [RNA-Seq 2]

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 [RNA-Seq 2]

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 [ChIP-Seq 2]

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 [ChIP-Seq 2]

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Gene expression profiles of CARM1 overexpression in MCF7

Project description:The goal of this study is to identify ERalpha-target genes affected by overexpression of the histone arginine methyltransferase CARM1 in breast cancer cells. The roles of CARM1 in ERalpha+ breast cancer was not well characterized. Therefore, we created a Dox inducible CARM1 overexpressing MCF7 cell line where CARM1 is overexpressed by 2 fold to determine the created a Dox-inducible CARM1 overexpressing MCF7 cells for evaluation of the global effects of CARM1 on Eralpha-target gene expression. MCF7-tet-on-CARM1 clone 13 were treated under 4 conditions: DMSO; Dox; E2 (10nM); Dox+E2. In Dox+E2 condition, cells were pre-treated with Dox for 5 days before treating with E2 for 4 hours. 3 biological replicates were included and total of 12 samples were analyzed.

2011-06-01 | E-GEOD-26454 | biostudies-arrayexpress

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