Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Haemophilus influenzae biotype aegyptius strain:F1946

ABSTRACT: Study of the genome and virulence of Haemophilus influenzae biotype aegyptius strains associated with Brazilian Purpuric Fever - strain F1946

PROVIDER: PRJNA297155 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Haemophilus influenzae biotype aegyptius strain:F3042

Project description:Study of the genome and virulence of Haemophilus influenzae biotype aegyptius strains associated with Brazilian Purpuric Fever - strain F3042

| PRJNA297159 | ENA

Haemophilus influenzae biotype aegyptius strain:F3283

Project description:Study of the genome and virulence of Haemophilus influenzae biotype aegyptius strains associated with Brazilian Purpuric Fever - strain F3283

| PRJNA297161 | ENA

Haemophilus influenzae biotype aegyptius strain:F3030

Project description:Study of the genome and virulence of Haemophilus influenzae biotype aegyptius strains associated with Brazilian Purpuric Fever - strain F3030

| PRJNA297156 | ENA

Haemophilus influenzae biotype aegyptius strain:F3039

Project description:Study of the genome and virulence of Haemophilus influenzae biotype aegyptius strains associated with Brazilian Purpuric Fever - strain F3039

| PRJNA297158 | ENA

Haemophilus influenzae biotype aegyptius strain:KC1018

Project description:Study of the genome and virulence of Haemophilus influenzae biotype aegyptius strains associated with Brazilian Purpuric Fever - strain KC1018

| PRJNA297162 | ENA

SWATH-MS demonstrates changes to protein expression due to a phase variable methyltransferase, ModA16, in Haemophilus influenzae biotype aegyptius

Project description:Cytoplasmic DNA methyltransferases are often associated with restriction modification (R-M) systems in bacterial systems. Phase variable expression of these DNA methyltransferase results in epigenetic regulation of multiple genes as part of systems called phasevarions (phase-variable regulons). H. aegyptius is the causative agent of Brazilian Purpuric Fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. We have recently described a previously unidentified allele of a phase variable Type III DNA methylstransferase in H. aegyptius, ModA16. When ModA16 is expressed, H. aegyptius strains exhibit differential methylation throughout the genome compared to when ModA16 is not expressed. This change in methylation results in altered gene expression and SWATH-MS was used to identify the resulting changes to protein expression. This dataset represents triplicate repeats from strains which express ModA16 (ON) and strains which do not (OFF).

2023-11-15 | PXD036097 | Pride

Haemophilus influenzae HK1212

Project description:Isolated from Australian patient with Brazilian purpuric fever

| PRJNA20115 | ENA

Haemophilus aegyptius

Project description:Causative agent for conjunctivitis and purpuric fever

| PRJNA53133 | ENA

Inflammatory response of Haemophilus influenzae biotype aegyptius causing Brazilian Purpuric Fever.

Project description:The Brazilian Purpuric Fever (BPF) is a systemic disease with many clinical features of meningococcal sepsis and is usually preceded by purulent conjunctivitis. The illness is caused by Haemophilus influenza biogroup aegyptius, which was associated exclusively with conjunctivitis. In this work construction of the las gene, hypothetically responsible for this virulence, were fusioned with ermAM cassette in Neisseria meningitidis virulent strains and had its DNA transfer to non BPF H. influenzae strains. The effect of the las transfer was capable to increase the cytokines TNFα and IL10 expression in Hec-1B cells line infected with these transformed mutants (in eight log scale of folding change RNA expression). This is the first molecular study involving the las transfer to search an elucidation of the pathogenic factors by horizontal intergeneric transfer from meningococci to H. influenzae.

| S-EPMC4323322 | biostudies-literature

Haemophilus influenzae

Project description:Haemophilus influenzae

| PRJNA387591 | ENA