Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Avian paramyxovirus 1 isolate:duck/Nigeria/NG-695/KG.LOM.11-16/2009

ABSTRACT: avian paramyxovirus 1 isolate:duck/Nigeria/NG-695/KG.LOM.11-16/2009 Genome sequencing and assembly

PROVIDER: PRJNA298993 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

avian paramyxovirus 8

Project description:avian paramyxovirus 8 Genome sequencing

| PRJNA213664 | ENA

INCREASED HEAT SHOCK PROTEIN 70 EXPRESSION BY CM-695 ASSOCIATES WITH STRONG ANTITROMBOTIC EFFECT WITHOUT INCREASING BLEEDING

Project description:BACKGROUND Antithrombotic medications target coagulation factors. Their use is associated with an increased bleeding risk. Safer drugs are needed. We described that the heat shock protein 70 (Hsp70) exhibits antithrombotic properties that do not influence bleeding. OBJECTIVES By using murine models, we want to test the hypothesis that overexpressing Hsp70 with CM-695, a dual inhibitor of HDAC6 and phosphodiesterase 9, protects against thrombosis while leaves bleeding tendency unaltered. METHODS CM-695 was used to induce Hsp70 overexpression. Hsp70 overexpressing mice were submitted to three thrombosis-triggering procedures. The ferric chloride carotid artery model was used to compare the antithrombotic role of CM-695 and rivaroxaban, a direct oral anticoagulant. The mouse tail transection model was used to compare the bleeding tendency upon CM-695 or rivaroxaban administration. RESULTS Intraperitoneal (i.p.) 20 mg/kg CM-695 increased Hsp70 expression markedly in the murine aortic tissue. This treatment delayed thrombosis in the collagen/epinephrine [P=0.04 (Log-Rank test), n=10], Rose Bengal/laser [median vessel occlusion time (OT): 58.6 vs. 39.0 minutes (min) in the control group (CG), P=0.008, n≥10] and ferric chloride (OT: 14.7 vs. 9.2 min in the CG, P=0.032, n≥10) models. I.p. 80 mg/kg CM-695 (n≥9) and intravenous 3 mg/kg rivaroxaban (n≥8) significantly delayed thrombosis. CM-695 did not induce bleeding [median bleeding time (BT): 8.5 vs. 7.5 min in the CG, n≥10]. However, this was dramatically increased by rivaroxaban (BT: 30.0 vs. 13.7 min in the CG, P=0.001, n=10). CONCLUSIONS CM-695 is a new antithrombotic drug devoid of bleeding risk that may be envisioned as a useful clinical tool.

2020-01-13 | GSE93958 | GEO

Malacoplasma iowae 695

Project description:Malacoplasma iowae 695 Genome sequencing

| PRJNA503681 | ENA

avian paramyxovirus 1

Project description:avian paramyxovirus 1 Raw sequence reads

| PRJNA1064681 | ENA

Pigeon paramyxovirus 1

Project description:Pigeon paramyxovirus 1 Genome sequencing and assembly

| PRJNA788372 | ENA

Malacoplasma iowae 695

Project description:Malacoplasma iowae 695 Genome sequencing and assembly

| PRJNA68271 | ENA

Expression data from two neutrophil subsets during murine paramyxovirus type 1 infection

Project description:Two subsets of neutrophils, separated by CD49d expression, are present in the airways of mice during an acute respiratory infection from murine paramyxovirus type 1 (SeV). We used microarrays to compare the transcriptomes of these two subsets to look for up-regulated or down-regulated genes that would account for the seemingly different funtions of the neutrophil subsets.

2017-12-01 | GSE61137 | GEO

Xanthomonas euvesicatoria strain:695

Project description:Xanthomonas euvesicatoria strain 695 Genome sequencing

| PRJNA275505 | ENA

Zea mays cultivar:RSQ-695

Project description:Zea mays RSQ-695 Transcriptome

| PRJNA493423 | ENA

RNA sequencing for enteroids treated with different concentrations of IL-17 (0 ng/ml. 1 ng/ml, 10 ng/ml and 100 ng/ml)

Project description:RNA sequencing for enteroids treated with different concentrations of IL-17 (0 ng/ml. 1 ng/ml, 10 ng/ml and 100 ng/ml)

| PRJNA756286 | ENA