Project description:The NIDDM-Atherosclerosis Study, funded by NHLBI, was designed as a family study to examine the genetic basis of subclinical atherosclerosis and diabetes in Hispanic families. Family members of probands with T2D were recruited in the Los Angeles area. The baseline examination of the cohort included the euglycemic hyperinsulinemic clamp test from which the two key phenotypes were obtained: insulin sensitivity (M) and metabolic clearance rate of insulin (MCRI). Genome-wide genotyping was obtained under separate funding by NIDDK as a part of the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.

| phs001130 | dbGaP

GUARDIAN: Mexican-American Coronary Artery Disease Study (MACAD)

Project description:GUARDIAN: Mexican-American Coronary Artery Disease Study (MACAD)

| PRJNA392714 | ENA

GUARDIAN: Mapping the Genes for Hypertension and Insulin Resistance (HTN-IR)

Project description:GUARDIAN: Mapping the Genes for Hypertension and Insulin Resistance (HTN-IR)

| PRJNA392193 | ENA

GUARDIAN: IRAS FAMILY STUDY (IRASFS)

Project description:TThe IRAS Family Study was a family study designed to examine the genetic and epidemiologic basis of glucose homeostasis traits and abdominal adiposity. Briefly, self-reported Mexican pedigrees were recruited in San Antonio, TX and San Luis Valley, CO. Probands with large families were recruited from the initial non-family-based IRAS Study, which was modestly enriched for impaired glucose tolerance and T2D. GUARDIAN includes 1,024 individuals in 88 pedigrees from the IRAS Family Study. Insulin sensitivity was obtained by FSIGT.

| phs001008 | dbGaP

STAMPEED: Family Heart Study SCAN - Genome Association Scan for Atherosclerosis Pathway Genes (Caucasians)

Project description:STAMPEED: Family Heart Study SCAN - Genome Association Scan for Atherosclerosis Pathway Genes (Caucasians)

| PRJNA75565 | ENA

GUARDIAN: IRAS (IRAS Classic)

Project description:The Insulin Resistance Atherosclerosis Study (IRAS) was an epidemiologic cohort study designed to examine the relationship between insulin resistance and carotid atherosclerosis across a range of glucose tolerance. Individuals of self-reported Mexican-American ethnicity were recruited in San Antonio, TX and San Luis Valley, CO. Recruitment was balanced across age and glucose tolerance status. GUARDIAN includes 173 individuals from the IRAS. Insulin sensitivity was obtained by FSIGT.

| phs001014 | dbGaP

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