Project description:<p>The Insulin Resistance Atherosclerosis Study (IRAS) was an epidemiologic cohort study designed to examine the relationship between insulin resistance and carotid atherosclerosis across a range of glucose tolerance. Individuals of self-reported Mexican-American ethnicity were recruited in San Antonio, TX and San Luis Valley, CO. Recruitment was balanced across age and glucose tolerance status. GUARDIAN includes 173 individuals from the IRAS. Insulin sensitivity was obtained by FSIGT.</p>

| phs001014 | dbGaP

Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.

Project description:Postoperative insulin resistance refers to the phenomenon that the body’s glucose uptake stimulated by insulin is reduced due to stress effects such as trauma or the inhibitory effect of insulin on liver glucose output is weakened after surgery. There is a clear link between postoperative insulin resistance and poor perioperative prognosis. Therefore, exploring interventions to reduce postoperative stress insulin resistance, stabilize postoperative blood glucose, and reduce postoperative complications are clinical problems that need to be solved urgently. In recent years, research on branched-chain amino acids and metabolic diseases has become a hot spot. Studies have found that in the rat model, preoperatively given a high branched-chain amino acid diet can inhibit postoperative insulin resistance and stabilize blood glucose levels. This research plan is to try to add branched-chain amino acids before surgery to observe the occurrence of postoperative insulin resistance in patients.

| 2744698 | ecrin-mdr-crc

GUARDIAN: Mexican-American Coronary Artery Disease Study (MACAD)

Project description:GUARDIAN: Mexican-American Coronary Artery Disease Study (MACAD)

| PRJNA392714 | ENA

Study the changes of amino acids and intestinal flora associated with insulin resistance in patients with colorectal cancer during Enhanced Recovery After Surgery (ERAS)

Project description:Interventions: Insulin resistance group:None Intervention;No insulin resistance group:None Intervention Primary outcome(s): Serum amino acid spectrum;Intestinal flora structure Study Design: Factorial

| 2692001 | ecrin-mdr-crc

NextGen Consortium: GENESiPS Study: Identifying the Gene Networks of Insulin Resistance

Project description:NextGen Consortium: GENESiPS Study: Identifying the Gene Networks of Insulin Resistance

| PRJNA324735 | ENA