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Drosophila melanogaster

ABSTRACT: The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity

PROVIDER: PRJNA300677 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2878340_1.fastq.gz	Fastqsanger.gz
	SRR2878340_2.fastq.gz	Fastqsanger.gz
	SRR2878341_1.fastq.gz	Fastqsanger.gz
	SRR2878341_2.fastq.gz	Fastqsanger.gz
	SRR2878333_1.fastq.gz	Fastqsanger.gz

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The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity

Project description:We identified Obelus, a conserved Ski2-family DExD/H-box helicase in a screen for Drosophila mutants with defects in epithelial polarity and junctional organization. To identify the functional targets of Obelus we used RNA sequencing and compared the transcriptional and splicing profiles of staged wild-type embryos with obe1/obe2 and obe2/Df(3R)Exel6174 (obe2/Df) mutant embryos.

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