Sarcoptes scabiei
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA304361 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR3229029_1.fastq.gz | Fastqsanger.gz | |||
| SRR3229029_2.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 2 of 2 |
Similar Datasets
Project description:Scabies is a human skin disease due to the burrowing ectoparasite Sarcoptes scabiei resulting in intense itching and inflammation and manifesting as skin allergy. Little is known about the specific scabies molecules and genes involved in the host inflammatory and immunologic responses. We interrogated the transcriptome profiles of skin biopsies using next generation sequencing and a combined clustering and pathway mapping approach which will enable us in the identification of key signaling events in the host immune and inflammatory responses to S. scabiei infestation. With the comprehensive analysis of RNA-seq results, it has been found that the immune response of host inhibits S. scabiei immune pathway, proliferation and metabolism signaling pathways, out of which the signaling pathway seems to be the main pathway in innate immune response of S. scabiei. The analysis of immune pathway, hydrolase and allergen will contribute to the research of S. scabiei pathogenesis, diagnosis and development of vaccines.
2021-06-22 | GSE178563 | GEO
Project description:Chromosome-scale genome sequencing and assembly of Sarcoptes scabiei
| PRJNA749654 | ENA
Project description:mRNA-microRNA Analysis of Sarcoptes scabiei and Host Immune Interactions
| PRJNA320671 | ENA
Project description:RNA seq and functional annotation of Sarcoptes scabiei var. nyctereutis
| PRJDB6658 | ENA
Project description:Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a high throughput LC-MS/MS-based approach, we undertook the first comprehensive, large-scale proteomic investigation of egg and adult female stages of the scabies mite, Sarcoptes scabiei – one of the most important parasitic mites of humans and other animals worldwide. In total, 1,761 S. scabiei proteins were identified and quantified with high confidence. Bioinformatic analyses revealed differentially expressed proteins to be involved predominantly in biological pathways or processes including genetic information processing, energy (oxidative phosphorylation), nucleotide, amino acid, carbohydrate and/or lipid metabolism, and some adaptive processes. These proteomic data set will enable future molecular, biochemical and physiological investigations of early developmental stages of S. scabiei and the discovery of novel interventions targeting the egg stage, given its non-susceptibility to current acaricidal treatments.
2022-11-11 | PXD032148 | Pride
Project description:Background: The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. This mite causes a neglected tropical disease (NTD), called scabies - one of the commonest dermatological problems globally, resulting in major morbidity, disability, stigma and poverty. In hyperendemic situations, scabies is often associated with secondary opportunistic bacterial infections/diseases - a major concern in children. Although some stages of this mite can be treated with drugs, resistance against some drugs is emerging, and there is no vaccine available against scabies. Here, we report molecular resources (including a high-quality genome as well as transcriptomic and proteomic data sets) for S. scabiei to aid basic and applied research of this and related mites.
2020-09-08 | PXD016925 | Pride
Project description:Sarcoptes scabiei isolate:SSS_KF_BRIS2020 Genome sequencing and assembly
| PRJNA598457 | ENA
Project description:Sarcoptes scabiei var. suis Raw sequence reads
| PRJNA513944 | ENA
Project description:Sarcoptes scabiei isolate:Arlian Lab Genome sequencing and assembly
| PRJNA268368 | ENA