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Sarcoptes scabiei somatic proteomes

ABSTRACT: Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a high throughput LC-MS/MS-based approach, we undertook the first comprehensive, large-scale proteomic investigation of egg and adult female stages of the scabies mite, Sarcoptes scabiei – one of the most important parasitic mites of humans and other animals worldwide. In total, 1,761 S. scabiei proteins were identified and quantified with high confidence. Bioinformatic analyses revealed differentially expressed proteins to be involved predominantly in biological pathways or processes including genetic information processing, energy (oxidative phosphorylation), nucleotide, amino acid, carbohydrate and/or lipid metabolism, and some adaptive processes. These proteomic data set will enable future molecular, biochemical and physiological investigations of early developmental stages of S. scabiei and the discovery of novel interventions targeting the egg stage, given its non-susceptibility to current acaricidal treatments.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Sarcoptes Scabiei

TISSUE(S): Egg, Whole Body

DISEASE(S): Parasitic Infectious Disease

SUBMITTER: Tao Wang

LAB HEAD: Robin Beat Gasser

PROVIDER: PXD032148 | Pride | 2022-11-11

REPOSITORIES: Pride

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	._201109_Tao_TW-1349_1-1.raw	Raw
	._201109_Tao_TW-1349_1-2.raw	Raw
	._201109_Tao_TW-1349_1-3.raw	Raw
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	._201109_Tao_TW-1349_1-5.raw	Raw

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