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Mus musculus

ABSTRACT: RNA-seq analysis of hair follicle stem cell transcriptome upon loss of the transcription factor FOXC1

PROVIDER: PRJNA309874 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3126090.fastq.gz	Fastqsanger.gz
	SRR3126091.fastq.gz	Fastqsanger.gz
	SRR3126092.fastq.gz	Fastqsanger.gz
	SRR3126093.fastq.gz	Fastqsanger.gz
	SRR3126094.fastq.gz	Fastqsanger.gz

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RNA-seq analysis of hair follicle stem cell transcriptome upon loss of the transcription factor FOXC1

Project description:We report downstream gene expression changes in stem cells of the adult mouse hair follicle upon conditional ablating of the transcription factor Forkhead Box C1 transcription factor (FOXC1). Hair follicles undergo cycles of rest (telogen; Tel) and regeneration (anagen; Ana). As such, we performed our analysis on these two different stages of hair follicles. mRNA-sequencing of WT vs. Foxc1-conditional or inducible KO (Foxc1-cKO or iKO) hair follicle stem cells (HFSCs) purified from mouse dorsal back skin by flow-activated cell sorting (FACS).

2016-02-16 | E-GEOD-77256 | biostudies-arrayexpress

Foxc1 reinforces quiescence in hair follicle stem cells

Project description:Quiescent stem cells are periodically activated to maintain tissue homeostasis or occasionally called into action upon injury. Molecular mechanisms that constitutively maintain stem cell identity or promote stem cell proliferation and differentiation upon activation have been extensively studied. However, it is unclear how quiescent stem cells maintain identity and reinforce quiescence when they transition from quiescence to activation. Here we show mouse hair follicle stem cell compartment induces a transcription factor, Foxc1, when activated. Importantly, deletion of Foxc1 in the activated but not quiescent stem cells compromises stem cell identity, fails to re-establish quiescence and subsequently drives premature stem cell activation.These findings uncover a dynamic, cell-intrinsic mechanism employed by hair follicle stem cells to reinforce stemness in response to activation. Poly(A)-enriched transcriptome RNA-seq on HFSCs isolated in WT and K14Cre cKO mice at anagen and early telogen stage of hair cycle.

2016-02-05 | E-GEOD-67404 | biostudies-arrayexpress

RNA-seq analysis of hair follicle stem cell transcriptome upon loss of the transcription factor FOXC1

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Project description:Foxc1 reinforces quiescence in hair follicle stem cells

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Global analysis of genome accessibility in hair follicle stem cells

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Foxc1 reinforces quiescence in hair follicle stem cells

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Transcriptome analysis of hair follcile stem cell quiescence

Project description:Hair follicle stem cells(HFSCs) can transition between active and quiescent stages during normal hair cycle or would healing. Transcriptional regulation has been show to regulate the transition. Previous studies have shown that two transcription factor, Foxc1 and Nfatc1, can help maintain the stem cells in quiescent state, the deletion of either one could lead to precocious activation. Here, we collect the hair follicle stem cell at postnatal day 30 from both control mice, Nfatc1 knockout mice, Foxc1 knockout mice(downloaded) and Foxc1/Nfatc1 double knockout mice to study the transcriptional regulation network of HFSCs quiescence.

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Project description:Hair follicle stem cell gene profile

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Project description:RNA-Seq in hair follicle stem cell lineage

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