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Mus musculus

ABSTRACT: Genome-wide analysis of gene expression of IWR1/Y27632-maintained epiblast stem cells (EpiSCs)

PROVIDER: PRJNA310607 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3139090.fastq.gz	Fastqsanger.gz
	SRR3139091.fastq.gz	Fastqsanger.gz
	SRR3139092.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:Developmental equivalence of epiblast stem cells (EpiSCs)

| PRJNA198197 | ENA

Microarray analysis of EpiSCs undergoing reprogramming by Esrrb.

Project description:To characterize the reprogramming of epiblast stem cells (EpiSCs) into embryonic stem cells (ESCs) induced by Esrrb, we performed microarray analysis of Tet-on Esrrb EpiSCs after treatment with doxycycline (Dox).

2018-06-01 | E-MTAB-5341 | biostudies-arrayexpress

Mus musculus

Project description:Gene expression profile of Epiblast stem cells

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Developmental equivalence of epiblast stem cells (EpiSCs)

Project description:Epiblast stem cells (EpiSCs) were derived from the epiblast or the ectoderm (epi/ect) of pre-gastrula stage to late-bud stage mouse embryos. To identify if the EpiSCs retain any original stage specific characteristics or which developmental stage of epi/ect they most closely related to, we performed microarray analysis to compare the gene expression profile of multiple EpiSC lines with that of epi/ect of 7 different stages.

2013-09-15 | GSE46227 | GEO

Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages

Project description:Embryonic stem cells (ESCs) comprise at least two populations of cells with divergent states of pluripotency. Here, we show that epiblast stem cells (EpiSCs) also comprise two distinct cell populations that can be distinguished by the expression of a specific Oct4-GFP marker. These two subpopulations, Oct4-GFP positive and negative EpiSCs, are capable of converting into each other in vitro. Oct4-GFP positive and negative EpiSCs are distinct from ESCs with respect to global gene expression pattern, epigenetic profile, and Oct4 enhancer utilization. Oct4-GFP negative cells share features with cells of the late mouse epiblast and cannot form chimeras. However, Oct4-GFP positive EpiSCs, which only represent a minor EpiSC fraction, resemble cells of the early epiblast and can readily contribute to chimeras. Our findings suggest that the rare ability of EpiSCs to contribute to chimeras is due to the presence of the minor EpiSC fraction representing the early epiblast.

2011-02-24 | GSE17984 | GEO

ChIP-seq analysis of Esrrb, Nanog, Oct4, and Sox2 in EpiSCs undergoing reprogramming

Project description:To investigate the molecular mechanisms underlying the reprogramming of epiblast stem cells (EpiSCs) into embryonic stem cells (ESCs) induced by Esrrb, we performed ChIP-seq analysis of Esrrb, Nanog, Oct4, and Sox2 in Tet-on Esrrb EpiSCs after treatment with doxycycline (Dox).

2018-06-01 | E-MTAB-5342 | biostudies-arrayexpress

Expression profiles of two epiblast stem cell lines and one ES cell line

Project description:This analysis compares the expression profiles of E3 epiblast stem cells (hybrid background), T9 EpiSCs (129 inbred background), and OG2 ES cells.

2010-02-21 | GSE17131 | GEO

RNA-seq analysis of EpiSCs undergoing differentiation induced by EB formation

Project description:To examine global gene expression changes during differentiation of epiblast stem cells (EpiSCs) induced by embryoid body (EB) formation, we performed RNA-seq analysis.

2018-06-01 | E-MTAB-5343 | biostudies-arrayexpress

Expression profiles of ES cells, epiblast stem cells, and epiblast stem cells reverted to an ES-like state

Project description:This analysis compares the expression profiles of CGR8 ES cells, E3 epiblast stem cells, and E3R cells (E3 EpiSCs reverted to an ES-like state).

2010-02-21 | GSE17132 | GEO

Gene expression profiles of EpiSC-derived neural stem cell lines in comparison with EpiSC and embryonic CNS

Project description:Epiblast stem cells (EpiSCs) maintained in the medium with activin were freed from activin to elicit neural development, exposed to various strengths of Wnt signals, which may provide the initial stage of anteroposterior regional specificities, and placed in the culture condition to arrest neural development but expand cells as neural stem cells (NSCs) with epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF2).

2023-07-20 | GSE237042 | GEO

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