Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Caenorhabditis elegans

ABSTRACT: A Tunable Mechanism Determines the Transgenerational Duration of Small RNA Inheritance in C.elegans

PROVIDER: PRJNA311152 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3151640.fastq.gz	Fastqsanger.gz
	SRR3151650.fastq.gz	Fastqsanger.gz
	SRR3151660.fastq.gz	Fastqsanger.gz
	SRR3151641.fastq.gz	Fastqsanger.gz
	SRR3151651.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Caenorhabditis elegans

Project description:Transgenerational inheritance of an acquired small RNA-based antiviral response in C.elegans

| PRJNA148961 | ENA

A Tunable Mechanism Determines the Transgenerational Duration of Small RNA Inheritance in C.elegans

Project description:In C.elegans nematodes small RNAs enable transmission of epigenetic responses across multiple generations. While RNA interference (RNAi) inheritance mechanisms that enable “memorization” of ancestral responses are being elucidated, it is not known why or how, after a few generations, epigenetic effects are “forgotten”. We show that exposure to dsRNA activates a feedback loop that determines the duration of inherited silencing. We find that gene-specific RNAi responses dictate the transgenerational duration of RNAi responses mounted against unrelated genes, elicited separately in previous generations. RNA-seq analysis reveals that aside from silencing of genes with complementary sequences, dsRNA-induced RNAi affects the production of heritable endogenous small RNAs, which regulate the expression of RNAi factors. Manipulating genes in this feedback pathway changes the duration of heritable silencing. Active control of transgenerational effects could be adaptive, since ancestral responses would be detrimental if the environments of the progeny and the ancestors would differ.

2016-03-24 | GSE77654 | GEO

Caenorhabditis elegans

Project description:Transgenerational profiling of small non-coding RNAs in C.elegans RSD mutants

| PRJNA174089 | ENA

Caenorhabditis elegans

Project description:Transgenerational changes in small RNA profiles of C.elegans mutants lacking PRG-1

| PRJNA174370 | ENA

Caenorhabditis elegans

Project description:Untangling the Role of H3K9 Methylations in Transgenerational Small RNA Inheritance

| PRJNA374350 | ENA

Caenorhabditis elegans

Project description:Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

| PRJNA144879 | ENA

A membrane-associated condensate ensures paternal epigenetic inheritance in C. elegans

Project description:Transgenerational epigenetic inheritance (TEI) describes the transmission of gene-regulatory information across generations without altering DNA sequences. TEI allows priming of offspring towards changing environmental conditions and plays a role in the maintenance of gene silencing of selfish genetic elements like transposons. Small regulatory RNAs are well known to act in TEI, and can be transmitted via the male. Such inheritance via sperm requires dedicated mechanisms, as much of the cellular content is extruded during spermatogenesis. We identify a phase separation-based mechanism, which couples the paternal inheritance of a specific small RNA-bound silencing factor via S-palmitoylation to the transport of membranous organelles. Our findings uncover a thus far unknown paternal TEI mechanism, and describe a novel mode of transport of phase-separated condensates.

2021-03-26 | PXD019099 | Pride

Caenorhabditis elegans

Project description:Transgenerational inheritance of mitochondrial stress adaptation in C. elegans

| PRJNA339523 | ENA

MicroRNA-Directed siRNA Biogenesis in Caenorhabditis elegans

Project description:C.elegans small RNAs from HA::ALG-1, HA::ALG-2 and HA::RDE-1 IP and rde-1 mutants

2010-04-14 | GSE20649 | GEO

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

Project description:Life experiences trigger transgenerational small RNA-based responses in C. elegans nematodes1. Dedicated machinery ensures that heritable effects would re-set, typically after a few generations2,3. Here we show that isogenic individuals differ dramatically in the persistence of transgenerational responses. By examining lineages composed of >20,000 worms we reveal 3 inheritance rules: (1) Once a response is initiated, each isogenic mother stochastically assumes an “inheritance state”, establishing a commitment that determines the fate of the inheritance. (2) The response that each mother transfers is uniform in each generation of her descendants. (3) The likelihood that an RNAi response would transmit to the progeny increases the more generations the response lasts, according to a “hot hand” principle. Mechanistically, the different parental “inheritance states” correspond to global changes in the expression levels of endogenous small RNAs, immune response genes, and targets of the conserved transcription factor HSF-1. We show that these rules predict the descendants’ developmental rate and resistance to stress.

2020-08-24 | GSE149422 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data