Project description:A new ubiquitination site of CSB was identified and proved to play roles in oxidative stress repair. This study characterizes the gene expression signatures affected by CSB-K991R as compared to wild type and UBD mutant. Using Nimblegen microarray we identified differentially expressed genes in human fibroblasts derived from CS patients as compared to CSB reconstituted cell lines (wild type), also we found the similar gene expression patterns between K991R and UBD mutant derivatives.
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
