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Homo sapiens

ABSTRACT: RNA-Seq of SLNCR1 over-expression in the melanoma cell line A375

PROVIDER: PRJNA311990 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3168481_1.fastq.gz	Fastqsanger.gz
	SRR3168481_2.fastq.gz	Fastqsanger.gz
	SRR3168482_1.fastq.gz	Fastqsanger.gz
	SRR3168482_2.fastq.gz	Fastqsanger.gz
	SRR3168483_1.fastq.gz	Fastqsanger.gz

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Project description:To define the role of MAGE-A1 in melanoma growth and metastasis, we performed RNA-seq analysis on MAGE-A1 overexpression (OE) and knockdown (KD) models in A375 human melanoma cell line. Our results revealed that overexpression of MAGE-A1 dramatically promoted proliferation, migration, and invasion of human melanoma cells in vitro and down-regulated of MAGE-A1 inhibited tumor cell proliferation and invasion. Furthermore, MAGE-A1 exerts its tumor promoting activity via activating including ERK-MAPK signaling pathway by RNA-seq analysis. mRNA profiles of MAGE-A1 over expression (OE), knockdown (KD), pcDNA-vector control, and pRNAT-scramble control in A375 cell line were generated using Ion torrent

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