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Expression data from adult mouse brain regions following prenatal infection

ABSTRACT: Expression data from adult mouse brain regions following prenatal infection

PROVIDER: PRJNA312226 | ENA |

REPOSITORIES: ENA

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Expression data from adult mouse brain regions following prenatal infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Expression data from adult mouse brain regions following prenatal infection

Project description:This SuperSeries is composed of the SubSeries listed below.

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Expression data from adult mouse Prefrontal Cortex following prenatal infection

Project description:Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the prefrontal cortex of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the prefrontal Cortex.

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Expression data from adult mouse Nucleus Accumbens following prenatal infection

Project description:Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the nucleus accumbens of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the nucleus accumbens.

2016-03-01 | E-GEOD-77971 | biostudies-arrayexpress

Expression data from adult mouse Nucleus Accumbens following prenatal infection

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Expression data from adult mouse Prefrontal Cortex following prenatal infection

2016-03-01 | GSE77972 | GEO

Epigenetic changes in the adult brain following exposure to prenatal maternal immune activation and dietary intervention

Project description:Epigenetic changes such as DNA cytosine methylation modulate gene function across brain and are implicated in the pathophysiology of neurodevelopmental disorders including schizophrenia and autism. Epigenetic changes can be caused by environmental exposures such as inflammation, and may at least partly explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. We used an MIA mouse model to investigate the postnatal epigenetic changes associated with exposure to the viral analogue PolyI:C. The effect of dietary supplement with omega-3 polyunsaturated fatty acids (PUFA) on exposed mice was also examined. Methylation was estimated genome-wide across gene regulatory regions. Widespread epigenetic changes were observed following exposure to inflammation during prenatal life. The differentially methylated gene set was enriched for genes involved in nervous system development and function. Omega-3 intervention modified the epigenetic profile, including a number of genes which were affected by MIA. These experiments indicate that environmental and genetic risk factors modulate similar biological pathways that are associated with neurodevelopmental disorders.

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Epigenetic profiling in adult brain after prenatal BPA exposure

Project description:Epigenetic profiling in adult brain after prenatal BPA exposure

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Epigenetic profiling in adult brain after prenatal BPA exposure [RRBS]

Project description:Epigenetic profiling in adult brain after prenatal BPA exposure [RRBS]

| PRJNA1047019 | ENA

Epigenetic profiling in adult brain after prenatal BPA exposure [ATAC-seq]

Project description:Epigenetic profiling in adult brain after prenatal BPA exposure [ATAC-seq]

| PRJNA1047021 | ENA