Metschnikowia spp.
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA312754 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| NKYU01.dat.gz | Other | |||
| NKYU01.fasta.gz | Fasta.gz | |||
| NKYU01.master.dat | Other | |||
| NKYV01.dat.gz | Other | |||
| NKYV01.fasta.gz | Fasta.gz |
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Project description:We analyzed differential gene expression in wt and a snf2 mutant (W8) cells; the pucherimin biosynthesis genes were among the top diff. regulated genes (reduced expression in the mutant). ABSTRACT: Metschnikowia pulcherrima synthesizes the pigment pulcherrimin, from cyclodileucine (cyclo(Leu-Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant pathogenic fungi. This yeast therefore has great potential for biocontrol applications against fungal diseases; particularly in the phyllosphere where this species is frequently found. To elucidate the molecular basis of the antifungal activity of M. pulcherrima, we compared a wildtype strain with a spontaneously occurring, pigmentless, weakly antagonistic mutant derivative. Whole genome sequencing of the wildtype and mutant strains identified a point mutation that creates a premature stop codon in the transcriptional regulator SNF2 in the mutant strain. Complementation of the mutant strain with the wildtype SNF2 gene restored pigmentation and recovered the strong antifungal activity. Mass spectrometry (UPLC HR HESI-MS) proved the presence of the pulcherrimin precursors cyclo(Leu-Leu) and pulcherriminic acid and identified new precursor and degradation products of pulcherriminic acid and/or pulcherrimin. All of these compounds were identified in the wildtype and complemented strain, but were undetectable in the pigmentless snf2 mutant strain. These results thus identify Snf2 as a regulator of antifungal activity and pulcherriminic acid biosynthesis in M. pulcherrima and provide a starting point for deciphering the molecular functions underlying the antagonistic activity of this yeast.
2019-09-01 | GSE128386 | GEO
Project description:This is genome-scale metabolic model of Candida albicans as the representative yeast species for the clade CUG-Ser1. This model was generated through homology search using a fungal pan-GEM largely based on Yeast8 for Saccharomyces cerevisiae, in addition to manual curation.
This model has been produced by the Yeast-Species-GEMs project from Sysbio (www.sysbio.se). This is model version 1.0.0 accompanying the publication (DOI: 10.15252/msb.202110427), currently hosted on BioModels Database and identified by MODEL2109130014. Further curations of this model will be tracked in the GitHub repository: https://github.com/SysBioChalmers/Yeast-Species-GEMs
Models for species of the same clade includes: Babjeviella inositovora; Candida albicans; Candida auris; Candida carpophila; Candida dubliniensis; Hyphopichia homilentoma; Candida intermedia; Candida orthopsilosis; Candida parapsilosis; Candida sojae; Suhomyces tanzawaensis; Yamadazyma tenuis; Candida tropicalis; Clavispora lusitaniae; Debaryomyces hansenii; Hyphopichia burtonii; Lodderomyces elongisporus; Metschnikowia aberdeeniae; Metschnikowia arizonensis; Metschnikowia bicuspidata var. bicuspidata; Metschnikowia borealis; Metschnikowia bowlesiae; Metschnikowia cerradonensis; Metschnikowia continentalis; Metschnikowia dekortorum; Metschnikowia drakensbergensis; Metschnikowia hamakuensis; Metschnikowia hawaiiensis; Metschnikowia hibisci; Metschnikowia ipomoeae; Metschnikowia kamakouana; Metschnikowia kipukae; Metschnikowia lochheadii; Metschnikowia matae var. matae; Metschnikowia matae var. maris; Metschnikowia mauinuiana; Metschnikowia proteae; Metschnikowia santaceciliae; Metschnikowia shivogae; Metschnikowia similis; Meyerozyma guilliermondii; Millerozyma acaciae; Priceomyces haplophilus; Scheffersomyces lignosus; Scheffersomyces stipitis; Spathaspora arborariae; Spathaspora girioi; Spathaspora gorwiae; Spathaspora hagerdaliae; Spathaspora passalidarum; Wickerhamia fluorescens; Priceomyces medius; Candida athensensis; Candida schatavii; Candida restingae; Aciculoconidium aculeatum; Kodamaea laetipori; Danielozyma ontarioensis; Candida oregonensis; Candida fructus; Candida corydali; Cephaloascus albidus; Cephaloascus fragrans; Suhomyces pyralidae; Suhomyces canberraensis; Suhomyces emberorum; Teunomyces kruisii; Teunomyces gatunensis; Teunomyces cretensis; Yamadazyma nakazawae; Priceomyces carsonii; Priceomyces castillae; Candida fragi; Hyphopichia heimii; Candida blattae; Yamadazyma philogaea; Yamadazyma scolyti; Meyerozyma caribbica; Kurtzmaniella cleridarum; Kodamaea ohmeri; Candida rhagii; Candida gotoi; Candida heveicola; Debaryomyces prosopidis; Debaryomyces nepalensis; Debaryomyces maramus; Candida hawaiiana; Debaryomyces subglobosus; Debaryomyces fabryi; Candida tammaniensis; Candida wancherniae; Candida ascalaphidarum; Candida golubevii; Candida gorgasii. These models are available in the zip file.
To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to MIT License for more information.
2021-11-01 | MODEL2109130014 | BioModels
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