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Orientia tsutsugamushi strain:AFSC7

ABSTRACT: Orientia tsutsugamushi strain:AFSC7 Genome sequencing and assembly

PROVIDER: PRJNA322209 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	LYMB01.dat.gz	Other
	LYMB01.fasta.gz	Fasta.gz
	LYMB01.master.dat	Other
	LYMB01.dat.gz	Other

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Project description:Emerging and neglected diseases pose challenges as their biology is frequently poorly understood, and genetic tools often do not exist to manipulate the responsible pathogen. Organism agnostic sequencing technologies offer a promising approach to understand the molecular processes underlying these diseases. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate intracellular bacterium and the causative agent of the vector-borne human disease scrub typhus. Half the Ot genome is composed of repetitive DNA, and there is minimal collinearity in gene order between strains. Integrating RNA-seq, comparative genomics, proteomics, and machine learning, we investigated the transcriptional architecture of Ot, including operon structure and non-coding RNAs, and found evidence for wide-spread post-transcriptional antisense regulation. We compared the host response to two clinical isolates and identified distinct immune response networks that are up-regulated in response to each strain, leading to predictions of relative virulence which were confirmed in a mouse infection model. Thus, dual RNA-seq can provide insight into the biology and host-pathogen interactions of a poorly characterized and genetically intractable organism such as Ot.

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