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Omics score: 0

Homo sapiens

ABSTRACT: Transcriptome of RA-responsive and RA-resistant breast cancer cell lines

OTHER RELATED OMICS DATASETS IN: PXD005911PXD004357

PROVIDER: PRJNA322613 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR3583291.fastq.gz	Fastqsanger.gz
	SRR3583292.fastq.gz	Fastqsanger.gz
	SRR3583293.fastq.gz	Fastqsanger.gz
	SRR3583294.fastq.gz	Fastqsanger.gz

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Phosphoproteome of RA-responsive and RA-resistant breast cancer cell lines

Project description:Retinoic acid (RA), the main active vitamin A metabolite, controls multiple biological processes such as cell proliferation and differentiation through genomic programs and kinase cascades activation. Due to these properties, RA has proven anti-cancer capacity. Several breast cancer cells respond to the antiproliferative effects of RA, while others are RA-resistant. However, the overall signaling and transcriptional pathways that are altered in such cells have not been elucidated. Here, in a large-scale analysis of the phosphoproteins and in a genome-wide analysis of the RA-regulated genes, we compared two human breast cancer cell lines, a RA-responsive one, the MCF7 cell line, and a RA-resistant one, the BT474 cell line, which depicts several alterations of the "kinome".

2020-10-15 | PXD005911 | Pride

Phosphoproteome of RA-responsive and RA-resistant breast cancer cell lines

2016-07-05 | PXD004357 | Pride