Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

ABSTRACT: Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

PROVIDER: PRJNA325276 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (mouse) Studies in Single Day Study using Illumina Array

Project description:The goal of this project was to determine gene expression changes in the liver at different times post treatment with the common freshwater cyanobacterial toxin, cylindrospermopsin (CYN). The liver is generally considered to be the primary target of this toxin and all the data has been derived from livers of exposed animals as well as concurrent controls. Preliminary gene expression effects have been reported (Chernoff et al., 2010) and the current data extend the time course from 1 hour post exposure to 1-day post cessation of a 5-day period dosing period. Gene expression changes were determined in the livers of pregnant mice exposed to toxic levels of cyanobacterial toxin, cylindrospermopsin. Animals were exposed to a dose of CYN that elicited significant hepatic toxicity. This single dose study analyzed liver samples collected at 1, 3, 6, 12 and 24 hours post dose. Gene expression changes were analyzed on the Illumina MouserRef-8v2.0 expression beadchip.

2016-06-24 | E-GEOD-83197 | biostudies-arrayexpress

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Single Day Study using Affymetrix Array

2016-06-24 | E-GEOD-83199 | biostudies-arrayexpress

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Multi-day Study using Affymetrix Array

Project description:The goal of this project was to determine gene expression changes in the liver at different times post treatment with the common freshwater cyanobacterial toxin, cylindrospermopsin (CYN). The liver is generally considered to be the primary target of this toxin and all the data has been derived from livers of exposed animals as well as concurrent controls. Preliminary gene expression effects have been reported (Chernoff et al., 2010) and the current data extend the time course from 1 hour post exposure to 1-day post cessation of a 5-day period dosing period. Gene expression changes were determined in the livers of pregnant mice exposed to toxic levels of the cyanobacterial toxin, cylindrospermopsin. Animals were exposed to a dose of CYN that elicited significant hepatic toxicity. This multi-day study used tissue obtained 1-day, 2-days, 4-days, and 5-days after the initiation of a 5 consecutive day dosing regimen. Toxicity data including gross observations, necropsy findings and clinical chemistry endpoints indicative of hepatic, renal and homeostasis functions were collected at the same time liver tissues for gene expression analysis were obtained. Gene expression changes were analyzed on the GeneChipÂ® Mouse Genome 430 2.0 Array.

2016-06-24 | E-GEOD-83198 | biostudies-arrayexpress

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Single Day Study using Affymetrix Array

2016-06-24 | GSE83199 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Multi-day Study using Affymetrix Array

2016-06-24 | GSE83198 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (mouse) Studies in Single Day Study using Illumina Array

2016-06-24 | GSE83197 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-06-24 | GSE83201 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-24 | E-GEOD-83201 | biostudies-arrayexpress

Feces of laboratory animals

Project description:Feces of laboratory animals Raw sequence reads

| PRJNA847356 | ENA

Comparative analysis of transcriptional profiles of adult Schistosoma japonicum from different laboratory animals and the natural host, water buffalo

Project description:Although numerous researches on schistosomiasis japonica have been performed using laboratory animal models, the comparison of gene expression profiles of S. japonicum from the different laboratory animals and natural hosts is still a gap. We systematically compared the gene expression profiles of schistosomes from different laboratory animals and water buffaloes. The findings of this study provide the basis for schistosomiasis research in different mammalian hosts at transcriptional level and valuable resource for the screening of anti-schistosomal intervention targets.

2015-07-19 | GSE65327 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data