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Mus musculus

ABSTRACT: Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1 [RRBS]

PROVIDER: PRJNA328811 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3880176_1.fastq.gz	Fastqsanger.gz
	SRR3880176_2.fastq.gz	Fastqsanger.gz
	SRR3880177_1.fastq.gz	Fastqsanger.gz
	SRR3880177_2.fastq.gz	Fastqsanger.gz

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Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1

Project description:Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1

| PRJNA328805 | ENA

Mus musculus

Project description:Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1 [ChIP-Seq]

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Mus musculus

Project description:Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1 [RNA-Seq]

| PRJNA328812 | ENA

Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1 [RRBS]

Project description:Environmental cues during gestation could exert transgenerational effects on behavior mainly through changes in epigenetic marks such as DNA methylation. However, the role of histone modifications in the inheritance of acquired phenotypes remains largely unknown in mammals. Here, we report that gestational choline supplementation (GCS) in maternal mice exerts anxiolytic effects on male offspring across 2 generations. Correspondingly, GCS-induced H3K9 hyperacetylation in the Nr3c1 promoter in male hippocampus leads to upregulation of Nr3c1 and its encoded protein, glucocorticoid receptor (GR), across 2 generations through the male germline. Furthermore, inhibition of CREB-binding protein (CBP) histone acetyltransferase (HAT) function restored GCS-induced epigenetic and behavioral alterations, suggesting that CBP function as a HAT to increase Nr3c1 expression through H3K9 hyperacetylation. Thus, GCS-induced GR upregulation through CBP-mediated H3K9 hyperacetylation in the Nr3c1 promoter is associated with anxiolytic behavior in male offspring, highlighting the role of histone modification in acquired phenotypes across mammalian generations.

2021-09-01 | GSE84316 | GEO

Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1 [RNA-Seq]

2021-09-01 | GSE84315 | GEO

Gestational choline supplementation improves cross-generational mood by epigenetic upregulation of Nr3c1 [ChIP-Seq]

2021-09-01 | GSE84314 | GEO

An exploratory study to examine the effects of maternal choline supplementation during mouse pregnancy on placental epigenetic markers (miRNA-seq data set)

Project description:This study sought to explore the effects of 4X maternal choline supplementation (MCS) on mRNA and miRNA abundance in mouse placentas collected on gestational day 15.5. These data advance our understanding about the importance of choline in reproductive health and will guide future mechanistic studies designed to elucidate the mechanisms mediating choline's beneficial effects.

2018-04-10 | GSE111295 | GEO

An exploratory study to examine the effects of maternal choline supplementation during mouse pregnancy on placental epigenetic markers (mRNA-seq data set)

2018-04-10 | GSE111294 | GEO

Modulation of liver cholesterol homeostasis by choline supplementation during fibrosis resolution

Project description:Liver fibrosis is a critical global health challenge, often leading to severe liver diseases without timely intervention. Choline deficiency has been linked to metabolic dysfunction associated steatohepatitis (MASH) and liver fibrosis, suggesting choline supplementation as a potential therapeutic approach. This study aimed to explore the therapeutic potential of choline supplementation in liver fibrosis resolution and its effects on cholesterol homeostasis using a mouse model with induced liver fibrosis. Our findings reveal that choline supplementation significantly decreases blood lactate dehydrogenase (LDH) and non-high-density lipoprotein cholesterol (non-HDL-C) levels. Transcriptome analysis showed that choline supplementation primarily induces genes related to cholesterol homeostasis, suggesting a significant impact on liver cholesterol synthesis. However, choline supplementation did not significantly alter the expression of fibrosis-related, choline metabolism-related, or epigenetics-related genes. This study provides novel insights into the role of choline in liver health and cholesterol metabolism, potentially informing treatments for liver fibrosis and related conditions.

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Effects of maternal choline intake on placental gene expression

Project description:To explore the influence of maternal choline intake on placental gene expression, we employed whole genome microarray expression profiling to identify genes that were differentially expressed in placental tissues obtained from women consuming two different doses (480 vs. 930 mg/d) of choline throughout the third trimester of pregnancy. Healthy third trimester (gestational week 26-29) pregnant women were randomized to a 12-week choline controlled feeding study. The participants consumed either 480 (n=6) or 930 (n=6) mg choline/d. Full thickness placental samples were collected at delivery to extract RNA and perform the arrays. Healthy third trimester (gestational week 26-29) pregnant women were randomized to a 12-week choline controlled feeding study. The participants consumed either 480 (n=6) or 930 (n=6) mg choline/d for 12 weeks. Placental samples were obtained at delivery

2012-07-12 | E-GEOD-39290 | biostudies-arrayexpress

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