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Mus musculus

ABSTRACT: TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells [RNA-seq]

PROVIDER: PRJNA329257 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3925050.fastq.gz	Fastqsanger.gz
	SRR3925041.fastq.gz	Fastqsanger.gz
	SRR3925051.fastq.gz	Fastqsanger.gz
	SRR3925042.fastq.gz	Fastqsanger.gz
	SRR3925052.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells [small RNA-seq]

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TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells

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Mus musculus Gata2 +9.5 Ets C>T transition untreated and 10 days post 5-FU LSK cells

Project description:The development and function of stem and progenitor cells that produce blood cells are vital in physiology. GATA2 mutations cause immunodeficiency, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). GATA-2 physiological activities necessitate that it be strictly regulated and cell type-specific enhancers fulfill this role. The +9.5 intronic enhancer harbors multiple conserved cis-elements, and germline mutations of these cis-elements are pathogenic in humans. Since mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology are unclear, we generated mouse models of the enhancer mutations. While a multi-motif mutant was embryonic lethal, a single-nucleotide Ets motif mutant was viable and steady-state hematopoiesis was normal. However, the Ets motif mutation abrogated stem/progenitor cell regeneration following stress. These results reveal a new mechanism in human genetics in which a disease mutation inactivates enhancer regenerative activity, while sparing developmental activity. Mutational sensitization to stress that instigates hematopoietic failure constitutes a paradigm for GATA-2-dependent pathogenesis.

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Mus musculus Stra8-deficient fetal ovary transcriptome

Project description:Identification of the mouse embryonic germ cell Stra8-/- transcriptome

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Project description:Identification of the mouse embryonic germ cell Dazl-/- transcriptome

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Mus musculus

Project description:Expression regulation by Pcgf6 in mouse embryonic stem cells

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Mus musculus

Project description:p/CIP gene regulation in mouse embryonic stem cells

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Bidirectional Introgression between Mus musculus domesticus and Mus spretus.

Project description:Introgressed variants from other species can be an important source of genetic variation because they may arise rapidly, can include multiple mutations on a single haplotype, and have often been pretested by selection in the species of origin. Although introgressed alleles are generally deleterious, several studies have reported introgression as the source of adaptive alleles-including the rodenticide-resistant variant of Vkorc1 that introgressed from Mus spretus into European populations of Mus musculus domesticus. Here, we conducted bidirectional genome scans to characterize introgressed regions into one wild population of M. spretus from Spain and three wild populations of M. m. domesticus from France, Germany, and Iran. Despite the fact that these species show considerable intrinsic postzygotic reproductive isolation, introgression was observed in all individuals, including in the M. musculus reference genome (GRCm38). Mus spretus individuals had a greater proportion of introgression compared with M. m. domesticus, and within M. m. domesticus, the proportion of introgression decreased with geographic distance from the area of sympatry. Introgression was observed on all autosomes for both species, but not on the X-chromosome in M. m. domesticus, consistent with known X-linked hybrid sterility and inviability genes that have been mapped to the M. spretus X-chromosome. Tract lengths were generally short with a few outliers of up to 2.7 Mb. Interestingly, the longest introgressed tracts were in olfactory receptor regions, and introgressed tracts were significantly enriched for olfactory receptor genes in both species, suggesting that introgression may be a source of functional novelty even between species with high barriers to gene flow.

| S-EPMC8784167 | biostudies-literature

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