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Homo sapiens

ABSTRACT: Ultrasound-mediated ultra effective cellular reprogramming of human fibroblasts into neural progenitor-like cells [MBD-Seq]

PROVIDER: PRJNA343882 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4289486_1.fastq.gz	Fastqsanger.gz
	SRR4289486_2.fastq.gz	Fastqsanger.gz
	SRR4289487_1.fastq.gz	Fastqsanger.gz
	SRR4289487_2.fastq.gz	Fastqsanger.gz
	SRR4289488_1.fastq.gz	Fastqsanger.gz

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Homo sapiens

Project description:Ultrasound-mediated effective neural progenitor cellular reprogramming

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Ultrasound-mediated ultra effective cellular reprogramming of human fibroblasts into neural progenitor-like cells

Project description:Ultrasound-mediated ultra effective cellular reprogramming of human fibroblasts into neural progenitor-like cells

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Ultrasound-mediated ultra effective cellular reprogramming of human fibroblasts into neural progenitor-like cells [MBD-Seq]

Project description:We have developed an ultra effective method of triggering fast cellular reprogramming into neural progenitor cells (NPCs) with significant yields, called ultrasound-directed permeation of environmental transition-guided cellular reprogramming (Entr).

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Project description:Ultrasound-mediated ultra effective cellular reprogramming of human fibroblasts into neural progenitor-like cells [RNA-Seq]

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An ultra effective method of generating extra multipotent cells from human fibroblasts via ultrasound-directed instant chromatin remodeling [MBD-seq]

Project description:We have developed an ultra effective method of generating extra multipotent (xpotent) cells which have differentiation potential more than limited cell types, by the mechanism of ultrasound-directed permeation of environmental transition-guided cellular reprogramming (Entr).

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An ultra effective method of generating extra multipotent cells from human fibroblasts via ultrasound-directed instant chromatin remodeling

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Project description:An ultra effective method of generating extra multipotent cells from human fibroblasts via ultrasound-directed instant chromatin remodeling [MBD-seq]

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Project description:Exosome-mediated direct conversion of human fibroblasts into neural progenitor-like cells [MBD-seq]

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Genome-wide chromatin binding of Elk1 and Gli2 in chemical induced neural reprogramming

Project description:Cellular reprogramming using chemically defined conditions, without genetic manipulation, is a promising approach for generating clinically relevant cell types for regenerative medicine and drug discovery. However, small molecule-driven approaches for inducing lineage-specific stem cells from somatic cells across lineage boundaries have been challenging to develop. Here, we report highly efficient reprogramming of mouse fibroblasts into induced neural stem cell-like cells (ciNSLCs) using a cocktail of nine small molecules (M9). The resulting ciNSLCs closely resemble primary neural stem cells molecularly and functionally. Transcriptome analysis revealed that M9 induces a gradual and specific conversion of fibroblasts towards a neural fate. During reprogramming specific transcription factors such as Elk1 and Gli2 that are downstream of M9-induced signaling pathways bind and activate endogenous master neural genes to specify neural identity. Our study therefore provides an effective chemical approach for generating neural stem cells from mouse fibroblasts, and reveals mechanistic insights into underlying reprogramming process. Genome-wide binding of Elk1 and Gli2 was analyzed by CHIP-seq for tdMEFs from day 0 (ciNSLC), day 4 (D4), day 8 (D8) of M9-induced neural reprogramming, and ciNSLCs and pri-NPC.

2016-05-15 | E-GEOD-78976 | biostudies-arrayexpress

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