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Homo sapiens

ABSTRACT: Specific expression of novel long non-coding RNAs in high-hyperdiploid childhood ALL

PROVIDER: PRJNA350700 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4453585.fastq.gz	Fastqsanger.gz
	SRR4453585_1.fastq.gz	Fastqsanger.gz
	SRR4453585_2.fastq.gz	Fastqsanger.gz
	SRR4453588.fastq.gz	Fastqsanger.gz
	SRR4453588_1.fastq.gz	Fastqsanger.gz

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Specific expression of novel long non-coding RNAs in high-hyperdiploid childhood ALL

Project description:Pre-B cell childhood acute lymphoblastic leukemia (pre-B cALL) is a heterogeneous disease involving many subtypes typically stratified using a combination of cytogenetic and molecular-based assays. These methods, although widely used rely on the presence of known chromosomal translocations, which is a limiting factor. There is therefore a need for robust, sensitive, and specific molecular biomarkers unaffected by such limitations that would allow better risk stratification and consequently better clinical outcome. In this study we performed a transcriptome analysis of 56 pre-B cALL patients to identify expression signatures in different subtypes. In both protein-coding and long non-coding RNAs (lncRNA), we identified subtype-specific gene signatures distinguishing pre-B cALL subtypes, particularly in t(12;21) and hyperdiploid cases. The genes up-regulated in pre-B cALL subtypes were enriched in bivalent chromatin marks in their promoters. LncRNAs is a new and under-studied class of transcripts. The subtype-specific nature of lncRNAs suggests they may be suitable clinical biomarkers to guide risk stratification and targeted therapies in pre-B cALL patients.

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