Project description:To determine te circular expression profile in collagen-induced arthritis (CIA) rats and normal rats, we uesed Arraystar Rat circRNA Array to examine the expression of circRNAs in CIA and normal rats' synovial tissues.
Project description:To determine te lncRNA expression profile in collagen-induced arthritis rats and normal rats, we uesed lncRNA microArray analysis form Arraystar to examine the expression of lncRNAs in CIA and normal rats' synovial tissues.
Project description:Identify HIP1 binding proteins implicated in regulation of invasive property of Rheumatoid Arthritis (RA) fibroblast-like synoviocytes (FLS) by using FLS cell line from arthritic DA (highly invasive) and R6 (minimally invasive) arthritis-protected congenic rats, which differ in amino-acid changing HIP1 SNPs.
Project description:The progression of arthritis involves sequential regulation of catabolic and anabolic genes that degenerate cartilages. We used microarrays to determine temporal regulation of genes during the progression of monoiodoacetate-induced arthritis in the knees of rats. Experimental arthritis was induced by intra-articular injection of monoiodoacetate (2 mg/ 50 ul) in the knees of rats. Cartilages from distal end of femur were collected on day 5, 9 and 21 post-injection. Saline injection was used as a sham control.
Project description:The progression of arthritis involves sequential regulation of catabolic and anabolic genes that degenerate cartilages. We used microarrays to determine temporal regulation of genes during the progression of monoiodoacetate-induced arthritis in the knees of rats.
