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Danio rerio

ABSTRACT: Development of zebrafish medulloblastoma model by TALENs induced somatic gene inactivation methods

PROVIDER: PRJNA357051 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5099111.fastq.gz	Fastqsanger.gz
	SRR5099112.fastq.gz	Fastqsanger.gz
	SRR5099113.fastq.gz	Fastqsanger.gz

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Danio rerio

Project description:Zebrafish Development

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Development of zebrafish medulloblastoma model by TALENs induced somatic gene inactivation methods

Project description:we developed the zebrafish cancer models by TALENs mediated somatic inactivation of tumor suppressor genes, rb1, induced brain tumors in tp53 mutation background. Using RNA sequencing analysis in addition to histopathology and immunohistochemistry, we demonstrated that the brain tumors induced by rb1 gene somatic inactivation have a molecular feature of MB-like PNETs

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Construction of Danio rerio Asymmetrical Maps (DreAM)

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