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Progesterone receptor transcriptome and cistrome in decidualized human endometrial stromal cells

ABSTRACT: Progesterone receptor transcriptome and cistrome in decidualized human endometrial stromal cells

PROVIDER: PRJNA368631 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2051516.fastq.gz	Fastqsanger.gz
	SRR2051517.fastq.gz	Fastqsanger.gz
	SRR2051518.fastq.gz	Fastqsanger.gz

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Progesterone receptor transcriptome and cistrome in decidualized human endometrial stromal cells

Project description:We report the whole genome binding profile of PGR and FOSL2 ChIP-seq in decidualizing human endometrial stromal cells

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Gene expression profiles of decidualized human endometrial stromal cells knockdown for HOXA10

Project description:The homeobox gene HOXA10 plays a key role in endometrial differentiation during embryogenesis and is abundantly expressed in the adult endometrium and decidual cells. In the adult endometrium the expression of HOXA10 is regulated by estrogen and progesterone and the levels are highest in the decidualized cells. We have shown that HOXA10 is required in the endometrial cells to maintain the decidual cell phenotype. In this study we aimed to determine the molecular mechanisms by which HOXA10 maintains the decidual phenotype and the other roles it might have in decidual physiology. In vitro decidualized human endometrial stromal cells were knocked down for HOXA10 using siRNA and gene expression profiles of the scrambled and HOXA10 siRNA transfected cells were compared at 24, 48 and 72 h post transfection. Several genes having multiple functions were found to be differentially expressed. We postulate that HOXA10 is required by the decidual cells to support immune cell differentiation, trophoblast invasion and cellular remodeling. In vitro decidualized priamry cultures of human endometrial strmal cells transfected with a siRNA againts HOXA10 or a scrambled siRNA. Cells harvested at 24, 48 and 72 h post transfection. Dual channel hybridization with dye swap design in biological replicates

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Gene expression profiles of decidualized human endometrial stromal cells knockdown for HOXA10

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Progesterone Receptor- and FOXO1-dependent transcriptomes decidualized human endometrial stromal cells

Project description:We report the gene expression profile of primary human endometrial stromal cells treated for 48 hours with control non-targeting, PGR-targeting, or FOXO1-targeting siRNA prior to decidualization stimulus for 72 hours.

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Project description:Expression profiles in decidualized and non-decidualized endometriotic cyst stromal cells (ECSCs) and normal endometrial stromal cells (NESCs)

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Project description:To identify the miRNAs which regulate endometrial decidualization, we explored differentially expressed miRNAs between untreated NESCs (n=4) and decidualized NESCs (n=4) using miRNA microarray. The miRNA expression profiles of untreated NESCs and decidualized NESCs were obtained, then the miRNAs were filtered by signal intensity (50.0<, at least one out of 8 samples have values within range) and flags (at least 13% of cases have good flags). We established the criteria for regulated genes: ratio ≥2.0-fold for up-regulated genes and ratio ≤0.5 for down-regulated genes.

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PCOS decidualised endometrial stromal cells present with altered effects of androgens

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