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Mus musculus

ABSTRACT: Effects of FTY720 on B cells in experimental autoimmune encephalomyelitis (EAE)

PROVIDER: PRJNA371644 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5236000_1.fastq.gz	Fastqsanger.gz
	SRR5236000_2.fastq.gz	Fastqsanger.gz
	SRR5236001_1.fastq.gz	Fastqsanger.gz
	SRR5236001_2.fastq.gz	Fastqsanger.gz
	SRR5236002_1.fastq.gz	Fastqsanger.gz

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Effects of FTY720 on B cells in experimental autoimmune encephalomyelitis (EAE)

Project description:MP4-induced experimental autoimmune encephalomyelitis (EAE) is a B cell-dependent mouse model of multiple sclerosis (MS), which enables targeted research on B cells, currently much discussed protagonists in MS pathogenesis. Here, we used this model to study the impact of the S1P1 receptor modulator FTY720 (fingolimod) on the autoreactive B cell and antibody response both in the periphery and central nervous system (CNS) itself.

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