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Bartonella grahamii

ABSTRACT: Bacterium that infects rodents

PROVIDER: PRJNA37245 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR1801742_1.fastq.gz	Fastqsanger.gz
	SRR1801742_2.fastq.gz	Fastqsanger.gz

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Bartonella grahamii

Project description:Bartonella grahamii Genome sequencing

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Bartonella spp. infection rate and B. grahamii in ticks.

Project description: Not available

| S-EPMC3471628 | biostudies-literature

Cat scratch disease caused by Bartonella grahamii in an immunocompromised patient.

Project description:Bartonella grahamii colonizes rodents worldwide and has been detected in questing Ixodes ricinus ticks. Here, the first human B. grahamii infection confirmed by multilocus sequence typing is reported. The route of transmission and clinical picture of the patient are similar to those seen in patients with cat scratch disease, which is typically diagnosed as a Bartonella henselae infection.

| S-EPMC3719609 | biostudies-literature

Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents.

Project description:BackgroundRodents represent a high-risk reservoir for the emergence of new human pathogens. The recent completion of the 2.3 Mb genome of Bartonella grahamii, one of the most prevalent blood-borne bacteria in wild rodents, revealed a higher abundance of genes for host-cell interaction systems than in the genomes of closely related human pathogens. The sequence variability within the global B. grahamii population was recently investigated by multi locus sequence typing, but no study on the variability of putative host-cell interaction systems has been performed.ResultsTo study the population dynamics of B. grahamii, we analyzed the genomic diversity on a whole-genome scale of 27 B. grahamii strains isolated from four different species of wild rodents in three geographic locations separated by less than 30 km. Even using highly variable spacer regions, only 3 sequence types were identified. This low sequence diversity contrasted with a high variability in genome content. Microarray comparative genome hybridizations identified genes for outer surface proteins, including a repeated region containing the fha gene for filamentous hemaggluttinin and a plasmid that encodes a type IV secretion system, as the most variable. The estimated generation times in liquid culture medium for a subset of strains ranged from 5 to 22 hours, but did not correlate with sequence type or presence/absence patterns of the fha gene or the plasmid.ConclusionOur study has revealed a geographic microstructure of B. grahamii in wild rodents. Despite near-identity in nucleotide sequence, major differences were observed in gene presence/absence patterns that did not segregate with host species. This suggests that genetically similar strains can infect a range of different hosts.

| S-EPMC2847970 | biostudies-literature

Bartonella grahamii as4aup

Project description:This strain will be used for comparative genome analysis

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Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis.

Project description:We describe the clinical and laboratory features of a 55-year-old human immunodeficiency virus-negative female patient who presented with bilateral intraocular inflammatory disease (neuroretinitis type) and behavioral changes caused by a Bartonella grahamii infection. Diagnosis was based on the PCR analysis of DNA extracted from the intraocular fluids. DNA analysis of the PCR product revealed a 100% identity with the 16S rRNA gene sequence of B. grahamii. The patient was successfully treated with doxycycline (200 mg/day) and rifampin (600 mg/day) for 4 weeks. This is the first report that demonstrates the presence of a Bartonella species in the intraocular fluids of a nonimmunocompromised patient and that indicates that B. grahamii is pathogenic for humans.

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Bartonella grahamii ATCC 700132

Project description:Bartonella grahamii ATCC 700132 Genome sequencing and assembly

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Bartonella grahamii strain:AU4XJBT

Project description:Bartonella grahamii strain:AU4XJBT Genome sequencing and assembly

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