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Streptococcus pyogenes

ABSTRACT: RocA regulates gene expression in serotype M1 group A Strep (GAS, aka S. pyogenes)

PROVIDER: PRJNA381406 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5408853.fastq.gz	Fastqsanger.gz
	SRR5408854.fastq.gz	Fastqsanger.gz
	SRR5408855.fastq.gz	Fastqsanger.gz

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Streptococcus pyogenes

Project description:Regulation of gene expression in serotype M1 group A Strep (GAS, aka S. pyogenes) by RocA

| PRJNA395857 | ENA

Stationary phase gene regulation in M1 GAS by the group A Streptococcus protein RocA

Project description:We used RNA-Seq to assess how RocA regulates gene expression in stationary phase cultures of serotype M1 GAS

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RocA regulates gene expression in serotype M1 group A Strep (GAS, aka S. pyogenes)

Project description:We used RNA-Seq to assess whether the rocA gene regulates gene expression in M1 GAS

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Regulation of gene expression in serotype M1 group A Strep (GAS, aka S. pyogenes) by RocA

Project description:We used RNA-Seq to assess whether the rocA gene regulates gene expression in M1 GAS

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Subcellular fractionation of Streptococcus pyogenes seotype M1

Project description:This data presents the complete proteomic subcellular characterization (extracellular secreted proteins, cell wall-associated proteins, cytosolic proteins, crude membrane proteins, peripheral membrane proteins and proteins present in purified membranes) of Streptococcus pyogenes serotype M1 (strain AP1).

2017-04-20 | MSV000080971 | MassIVE

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (initial)

Project description:A new variant of group A Streptococcus (GAS) serotype M1 (designated ‘M1UK’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor GAS ‘M1global’ and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1UK in Australia, now isolated from the majority of serious infections caused by serotype M1 GAS. M1UK sub-lineages circulating in Australia also contain a novel toxin repertoire associated with epidemic scarlet fever causing GAS in Asia. A single SNP in the M1UK tmRNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator readthrough in the M1UK lineage. This represents a new paradigm of toxin expression and urges enhanced international surveillance.

2023-01-30 | GSE212238 | GEO

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (second SP1448)

2023-01-30 | GSE212242 | GEO

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (second SP1380)

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Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (second 5448)

2023-01-30 | GSE212239 | GEO

Whole genome transcritptional comparison of Group A Streptococcus (Streptococcus pyogenes) serotype M1 pre-epidemic and epidemic isolates

Project description:This transcriptional analysis is a follow up to a population genomic investigation of 3615 Streptococcus pyogenes serotype M1 strains whch are responsible for an epidemic of human invasive infections (www.pnas.org/cgi/doi/10.1073/pnas.1403138111), The goal was to assess gene expression differences between predecessor pre-epidemic M1 strains and their descendent epidemic M1 strains to gain insights into the underlying genetic basis for the shift in the frequency and severity of human infections caused by these pathogenic bacteria The transcriptomes of 7 GAS M1 strains, 4 pre-epidemic and 3 epidemic, were compared at two phases of growth, mid-exponential and early-stationary, using 3 biologial replicates, to identify genes differentially expressed between the pre-epidemic and epidemic isolates with the goal of to gaining insight into the underlying genetic basis for the evolutionary emergence, increased frequency and severity of the epidemic strains relative to the pre-epidemic strains

2015-08-10 | E-GEOD-70496 | biostudies-arrayexpress

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