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Rattus norvegicus

ABSTRACT: Rat embryonic stem cells produce fertile offspring through tetraploid complementation [RRBS]

PROVIDER: PRJNA383541 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5457791_1.fastq.gz	Fastqsanger.gz
	SRR5457791_2.fastq.gz	Fastqsanger.gz
	SRR5457792_1.fastq.gz	Fastqsanger.gz
	SRR5457792_2.fastq.gz	Fastqsanger.gz
	SRR5457793_1.fastq.gz	Fastqsanger.gz

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Rattus norvegicus

Project description:Rat embryonic stem cells produce fertile offspring through tetraploid complementation [RNA-Seq]

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Rat embryonic stem cells produce fertile offspring through tetraploid complementation

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Rat embryonic stem cells produce fertile offspring through tetraploid complementation [RRBS]

Project description:Pluripotency of embryonic stem cells (ESCs) can be functionally assessed according to their developmental potency. Tetraploid complementation, through which an entire organism is produced from donor pluripotent cells, is taken as the most stringent test for pluripotency. It remains unclear whether ESCs from other species besides mice can pass this test. Here we show that the rat ESCs at very early passages are also capable to produce fertile offspring by tetraploid complementation, however, this capacity is rapidly lost during culture due to the loss of genomic imprinting. Our findings support that the naïve ground state pluripotency exists in rat and can be captured in rat ESCs, yet may be subjected to species-specific regulations, which have implications for the derivation and application of naïve pluripotent stem cells in other species including human.

2017-10-11 | GSE97968 | GEO

Rat embryonic stem cells produce fertile offspring through tetraploid complementation [RNA-Seq]

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Expression data from rat androgenetic embryonic stem cells

Project description:The rat androgenetic embryonic stem cells (RahES cells) have only 21 chromosomes. However, they express pluripotency markers, differentiate into three germ layer cells as well as contribute to the germline as the normal diploid rat ES cells. Moreover, the RahES cells can produce fertile rats after intracytoplasmic injection into oocytes, thus are capable to transmit genetic modifications to offspring. We used microarrays to detail the global gene expression profile of RahES cells and identified distinct classes of up-regulated and down-regulated genes compared with the expression of normal diploid rat ES cells.

2013-12-15 | GSE51806 | GEO

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2013-12-15 | E-GEOD-51806 | biostudies-arrayexpress

Radiation effects on gene expression in rat testes (Rattus norvegicus)

Project description:Analysis of LBNF1 rat testes from controls, containing both somatic and all germ cell types and from irradiated rats in which all cells germ cells except type A spermatgogonia are eliminated. Results provide insight into distinguishing germ and somatic cell genes and identification of somatic cell genes that are upregulated after irradiation.

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Transcriptome Profiling of Rattus norvegicus Embryonic Stem Cells by RNA-Sequencing

Project description:In order to establish a rat embryonic stem cell transcriptome, mRNA from rESC cell line DAc8, the first male germline competent rat ESC line to be described and the first to be used to generate a knockout rat model was characterized using RNA sequencing (RNA-seq) analysis.Â 2 biological replicates of RRRC#464 DA-EC8/Rrrc cell line were sequenced with 50bp paired end reads using Illumina Hi-Seq 2000

2016-09-02 | E-GEOD-44150 | biostudies-arrayexpress

Rattus norvegicus

Project description:Expression data from rat androgenetic embryonic stem cells

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