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Homo sapiens

ABSTRACT: Transcriptomic profile of circulating memory CD8 T cells can differentiate between latent tuberculosis individuals and healthy controls

PROVIDER: PRJNA388213 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5619960.fastq.gz	Fastqsanger.gz
	SRR5619970.fastq.gz	Fastqsanger.gz
	SRR5619980.fastq.gz	Fastqsanger.gz
	SRR5619990.fastq.gz	Fastqsanger.gz
	SRR5619961.fastq.gz	Fastqsanger.gz

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Transcriptomic profile of circulating memory CD8 T cells can differentiate between latent tuberculosis individuals and healthy controls

Project description:Tuberculosis (TB) is responsible for the majority of mortality and morbidity associated with infectious diseases worldwide. The characterization of exact molecular components of immune response associated with protection against TB may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of memory T cells associated with latent infection with Mycobacterium tuberculosis. Transcriptomic profiling using RNA sequencing was performed on memory CD8 T cells isolated from individuals with latent tuberculosis, as well as from tuberculosis negative healthy controls. Overall, we found specific gene signatures in each cell subset that could successfully discriminate between individuals with latent tuberculosis and healthy controls.

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Transcriptomic profile of circulating memory T cells can differentiate between latent tuberculosis individuals and healthy controls

Project description:Tuberculosis (TB) is responsible for the majority of mortality and morbidity associated with infectious diseases worldwide. The characterization of exact molecular components of immune response associated with protection against TB may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of memory T cells associated with latent infection with Mycobacterium tuberculosis. Transcriptomic profiling using RNA sequencing was performed on memory CD4 and CD8 T cells isolated from individuals with latent tuberculosis, as well as from tuberculosis negative healthy controls. Overall, we found specific gene signatures in each cell subset that could successfully discriminate between individuals with latent tuberculosis and healthy controls.

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Project description:Transcriptomic profile of circulating memory T cells can differentiate between latent tuberculosis individuals and healthy controls

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Project description:Transcriptomic profile of circulating memory CD4 T cells can differentiate between latent tuberculosis individuals and healthy controls

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Transcriptomic profile of circulating memory CD4 T cells can differentiate between latent tuberculosis individuals and healthy controls

Project description:Tuberculosis (TB) is responsible for the majority of mortality and morbidity associated with infectious diseases worldwide. The characterization of exact molecular components of immune response associated with protection against TB may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of memory T cells associated with latent infection with Mycobacterium tuberculosis. Transcriptomic profiling using RNA sequencing was performed on memory CD4 T cells isolated from individuals with latent tuberculosis, as well as from tuberculosis negative healthy controls. Overall, we found specific gene signatures in each cell subset that could successfully discriminate between individuals with latent tuberculosis and healthy controls.

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Project description:Tuberculosis (TB) is responsible for the majority of mortality and morbidity associated with infectious diseases worldwide. The characterization of exact molecular components of immune response associated with protection against TB may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of memory T cells associated with active versus latent infection with Mycobacterium tuberculosis. Transcriptomic profiling using RNA sequencing was performed on memory CD4 T cells isolated from individuals with active TB (at diagnosis and 2 months post treatment), latent TB, as well as from TB negative healthy controls. Overall, we found specific gene signatures for each cohort that could successfully discriminate between individuals with active TB at diagnosis, treated active TB, latent TB and healthy controls.

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