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Rattus norvegicus

ABSTRACT: RNA sequencing analysis of the Lewis versus Brown Norway rat, with or without Toxoplasma gondii infection

PROVIDER: PRJNA390980 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5712460.fastq.gz	Fastqsanger.gz
	SRR5712470.fastq.gz	Fastqsanger.gz
	SRR5712461.fastq.gz	Fastqsanger.gz
	SRR5712471.fastq.gz	Fastqsanger.gz
	SRR5712462.fastq.gz	Fastqsanger.gz

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RNA sequencing analysis of the Lewis versus Brown Norway rat, with or without Toxoplasma gondii infection

Project description:Rats vary in their susceptibilities to Toxoplasma gondii infection depending on the rat strain. Compared to the T. gondii-susceptible Brown Norway (BN) rat, the Lewis (LEW) rat is extremely resistant to T. gondii. Thus, these two rat strains are ideal models for elucidating host mechanisms that are important for host resistance to T. gondii infection. Therefore, in an attempt to unravel molecular factors directing the protective early innate immune responses in the LEW rat, we performed RNA sequencing analysis of the LEW versus BN rat, with or without T. gondii infection.

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Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus C4PR_LIV

Project description:Major urinary proteins (MUP) are the major component of the urinary protein fraction in house mice (Mus spp.) and rats (Rattus spp.). The structure, polymorphism and functions of these lipocalins have been well described in the western European house mouse (Mus musculus domesticus), clarifying their role in semiochemical communication. The complexity of these roles in the mouse raises the question of similar functions in other rodents, including the Norway rat, Rattus norvegicus. Norway rats express MUPs in urine but information about specific MUP isoform sequences and functions is limited. In this study, we present a detailed molecular characterization of the MUP proteoforms expressed in the urine of two laboratory strains, Wistar Han and Brown Norway, and wild caught animals, using a combination of manual gene annotation, intact protein mass spectrometry and bottom-up mass spectrometry-based proteomic approaches. Detailed sequencing of the urinary MUP isoforms reveals a less complex pattern of primary sequence polymorphism in the rat than the mouse. However, rat MUPs exhibit added complexity in the form of post-translational modifications, including the phosphorylation of Ser4 in some isoforms, and exoproteolytic trimming of specific isoforms.

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Project description:Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14).

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Project description:Genetic basis of rare arterial and renal phenotypes in the Brown Norway rat

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Genetic Influences on Asthma Susceptibility in Developing Lung

Project description:Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14). Total RNA obtained from whole lung of rat from 3 genetic strains and 3 postnatal time points in (mainly) quadruplicate measurements per strain and time point.

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Project description:Characteristics of Long Non-coding RNAs in the Brown Norway Rat and Alterations in the Dahl Salt-Sensitive Rat

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Project description:Time course expression data from Brown Norway rat livers treated with nevirapine or galactosamine or both

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Project description:Effects of diethylstilbestrol (DES) on the anterior pituitary gland of the ACI, Copenhagen and Brown Norway Rat.

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Project description:Gene expression in kidney from Lewis and Dahl(S) rat

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