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Heterogeneous responses of hematopoietic stem cells to inflammatory stimuli are altered with age

ABSTRACT: Heterogeneous responses of hematopoietic stem cells to inflammatory stimuli are altered with age

PROVIDER: PRJNA391714 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5750640_1.fastq.gz	Fastqsanger.gz
	SRR5750640_2.fastq.gz	Fastqsanger.gz
	SRR5750650_1.fastq.gz	Fastqsanger.gz
	SRR5750650_2.fastq.gz	Fastqsanger.gz
	SRR5750660_1.fastq.gz	Fastqsanger.gz

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Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.

Project description:Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a myeloid-biased output, resulting in poor immune responses to infectious challenge and the development of myeloid leukemias. Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. Using single-cell RNA sequencing (scRNA-seq), we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is prevalent among aged LT-HSCs. We identify CD61 as a marker of mLT-HSCs and show that CD61-high LT-HSCs are uniquely primed to respond to acute inflammatory challenge. We predict that several transcription factors regulate the mLT-HSCs gene program and show that Klf5, Ikzf1, and Stat3 play an important role in age-related inflammatory myeloid bias. We have therefore identified and isolated an LT-HSC subset that regulates myeloid versus lymphoid balance under inflammatory challenge and with age.

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Heterogeneous responses of hematopoietic stem cells to inflammatory stimuli are altered with age

Project description:This SuperSeries is composed of the SubSeries listed below.

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Heterogeneous responses of hematopoietic stem cells to inflammatory stimuli are altered with age - bulk

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Heterogeneous responses of hematopoietic stem cells to inflammatory stimuli are altered with age - single cell

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Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age

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Altered expression in sika deer skeletal muscle with age

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Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age

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