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Danio rerio

ABSTRACT: Nr2f transcription factors promote the identity of the vertebrate upper jaw

PROVIDER: PRJNA395253 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5855384_1.fastq.gz	Fastqsanger.gz
	SRR5855384_2.fastq.gz	Fastqsanger.gz
	SRR5855385_1.fastq.gz	Fastqsanger.gz
	SRR5855385_2.fastq.gz	Fastqsanger.gz
	SRR5855386_1.fastq.gz	Fastqsanger.gz

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Danio rerio

Project description:Accelerated cartilage differentiation distinguishes the lower from the upper vertebrate face

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The Gq/11 family of G alpha subunits is necessary and sufficient for lower jaw development

Project description:Development of the vertebrate jaw apparatus depends on highly conserved signaling pathways. Patterning of the lower jaw is driven by Endothelin receptor type A (Ednra) and secreted ligand Endothelin 1 (Edn1). The Ednra signaling pathway establishes the identity of lower jaw progenitors by regulating expression of numerous patterning genes, but the intracellular signaling mechanisms linking receptor activation to gene regulation remains poorly understood. As a first step towards addressing this question, we examined the function of the Gq/11 family of Gα subunits in zebrafish using pharmacological and genetic ablation of Gq/11 activity and transgenic induction of a constitutively active Gq protein in edn1-/- embryos. Loss of Gq/11 activity fully recapitulated the edn1-/- phenotype, with genes encoding for G11 being most essential. Furthermore, inducing Gq activity in edn1-/- embryos not only restored Ednra-dependent jaw structures and gene expression signatures but also caused homeosis of the upper jaw structures into a lower jaw-like structure. These results indicate that Gq/11 is necessary and sufficient to mediate the lower jaw patterning mechanism for Ednra.

2024-09-19 | GSE275013 | GEO

Danio rerio

Project description:Identifying Transcription Factors Expressed by V0v Spinal Cord Interneurons

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Nr2f transcription factors promote the identity of the vertebrate upper jaw

Project description:The jaws are complementary in form and function but develop asymmetrically, as the lower but not upper jaw bone forms around a prominent cartilage template. How such differences in skeletal composition are patterned is unclear. Here, we identify four Nuclear receptor 2f genes, nr2f1a, nr2f1b, nr2f2, and nr2f5, as enriched in zebrafish upper jaw precursors. Whereas loss of Nr2f genes results in expansion of upper jaw cartilage to resemble that of the lower jaw, Nr2f5 misexpression inhibits lower jaw cartilage formation. Genome-wide analyses show that Nr2f genes prevent expansion of lower jaw-associated gene expression into the upper jaw territory. Further, restriction of Nr2f expression by Endothelin1 signaling is critical for lower jaw development, as reducing Nr2f dosage fully restores lower jaw development in edn1 mutants. We propose that Nr2f genes drive jaw asymmetry by limiting early cartilage differentiation in the upper jaw to preserve more precursors for later osteogenesis.

2018-01-18 | GSE101719 | GEO

Danio rerio

Project description:AHR Activation by TCDD Downregulates Sox9b Expression Producing Jaw Malformation in Zebrafish Embryos

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Project description:N6-methyladenosine dynamics during early vertebrate embryogenesis

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