Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Genome-wide transcriptome in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure [RNA-seq]

PROVIDER: PRJNA397760 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5921280_1.fastq.gz	Fastqsanger.gz
	SRR5921280_2.fastq.gz	Fastqsanger.gz
	SRR5921290_1.fastq.gz	Fastqsanger.gz
	SRR5921290_2.fastq.gz	Fastqsanger.gz
	SRR5921281_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Genome-wide transcriptome in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

Project description:Genome-wide transcriptome in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

| PRJNA639582 | ENA

Mus musculus

Project description:DNA methylation profiling by MBD-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

| PRJNA397759 | ENA

RNA-Seq and H3K27ac ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

Project description:RNA-Seq and H3K27ac ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

| PRJNA639581 | ENA

Histone H3K27ac modification profiling by ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

Project description:Histone H3K27ac modification profiling by ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

| PRJNA639583 | ENA

Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells.

Project description:Developmental exposure to diethylstilbestrol (DES) causes reproductive tract malformations, affects fertility and increases the risk of clear cell carcinoma of the vagina and cervix in humans. Previous studies on a well-established mouse DES model demonstrated that it recapitulates many features of the human syndrome, yet the underlying molecular mechanism is far from clear. Using the neonatal DES mouse model, the present study uses global transcript profiling to systematically explore early gene expression changes in individual epithelial and mesenchymal compartments of the neonatal uterus. Over 900 genes show differential expression upon DES treatment in either one or both tissue layers. Interestingly, multiple components of the Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma)-mediated adipogenic/lipid metabolic pathway, including PPARgamma itself, are targets of DES in the neonatal uterus. TEM and Oil Red O staining further demonstrate a dramatic increase in lipid deposition in the uterine epithelial cells upon DES exposure. Neonatal DES exposure also perturbs glucose homeostasis in the uterine epithelium. Some of these neonatal DES-induced metabolic changes appear to last into adulthood, suggesting a permanent effect of DES on energy metabolism in uterine epithelial cells. This study extends the list of biological processes that can be regulated by estrogen or DES, and provides a novel perspective for endocrine disruptor induced reproductive abnormalities.

2012-05-15 | GSE37969 | GEO

Mus musculus

Project description:Gene expression profiling in the seminal vesicles (SVs) from neonatal DES-treated mice [array]

| PRJNA376602 | ENA

Gene expression and DNA methylation profiling in the seminal vesicles (SVs) from neonatal DES-treated mice

Project description:Gene expression and DNA methylation profiling in the seminal vesicles (SVs) from neonatal DES-treated mice

| PRJNA397752 | ENA

Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells.

2012-05-14 | E-GEOD-37969 | biostudies-arrayexpress

Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide

Project description:The seminal vesicles synthesise bioactive factors that support gamete function, modulate the female reproductive tract to promote implantation, and influence developmental programming of offspring phenotype. Despite the significance of the seminal vesicles in reproduction, their biology remains poorly defined. Here, to advance understanding of seminal vesicle biology, we analyse the mouse seminal vesicle transcriptome under normal physiological conditions and in response to acute exposure to the reproductive toxicant acrylamide. Mice were administered acrylamide (25 mg/kg bw/day) or vehicle control daily for five consecutive days prior to collecting seminal vesicle tissue 72 h following the final injection.

2021-09-14 | GSE183632 | GEO

Histone H3K27ac modification profiling by ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

Project description:DES is a synthetic estrogen that is associated with adverse effects on reproductive organs. Our group has employed estrogen receptor (ER) α knockout (αERKO) mice to gain insight into the contribution of ER α in DES-induced toxicity following neonatal exposure

2023-06-14 | GSE152524 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data