Gallus gallus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA399841 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:In order to characterize alterations in cellular regulatory mechanisms associated with MDV reactivation, we employed microarray analysis to identify changes in gene expression in chemically-reactivated MDV transformed cell lines, specifically MSB1, RP2 and CU115. Differentially expressed genes identified in the MDV-transformed cell lines were then compared against differentially expressed genes in the REV-transformed CU91 cell line. This step was done to reduce the number of false positives (i.e. genes likely responding solely to sodium butyrate rather than MDV reactivation). Multiple cellular pathways are also affected by MDV reactivation, including those associated with apoptosis, the cell cycle, DNA repair, and immune response.
2018-08-23 | GSE103028 | GEO
Project description:As a histone deacetylase inhibitor, sodium butyrate and its derivative sodium phenylbutyrate involve in cellular events such as proliferation, differentiation, apoptosis and cell cycle control via reprogramming gene expression. However, the gene associated with the cell cycle control and molecular signaling triggering cell apopotosis and death are not well elucidated. Here, we treated A549 cells,a cell line belong to the non-small cells lung cancer,with high concentration of sodium butyrate or sodium phenylbutyrate and then used microarray identified differentially-expressed mRNA during this process.
2017-06-10 | GSE86928 | GEO
Project description:Identification of differentially expressed genes in early inner ear development
| PRJNA117713 | ENA
Project description:Next Generation Sequencing Facilitates identification of genes differentially expressed during feather elongation
| PRJNA341275 | ENA
Project description:It is widely believed that the prevention of cancer is the most promising strategy for reducing both cancer incidence and cancer-related mortality. Dietary bioactive components have been found to modulate many dysregulated molecular pathways associated with the development of cancer. Epidemiological and pre-clinical data suggest that sodium butyrate and its derivatives possess chemopreventive properties. Specifically, the butyrate-containing structured lipid (STL) presented strong chemopreventive proprieties in experimental hepatocarcinogenesis. To determine the mechanistic basis, the hepatic transcriptomic profiles in rats submitted to a classic “resistant hepatocyte” model of hepatocarcinogenesis and treated with butyrate-containing STL were evaluated. A total of 1583 genes were found to be differentially expressed in the livers of rats treated with butyrate-containing STL. Pathways analysis of the differentially expressed genes demonstrated a strong enrichment in genes involved in epithelial mesenchymal transition, vasculogenesis, and cell proliferation. In conclusion, tumor-suppressing activity of butyrate containing STLs is associated with its ability to regulated major hepatocarcinogenesis-related pathways at early stages of rat liver carcinogenesis.
2018-01-26 | GSE109685 | GEO
Project description:Analysis of colorectal cancer (CRC) cell line HT-29 treated with Sodium Butyrate. Sodium Butyrate, a HDAC inhibitor present in gut, can differentiate the undifferentiated HT-29 to enterocytes by the induction of brush border enzyme alkaline phosphatase. Results provide the transcriptional profiling underlying the butyrate-induced differentiation of CRC.
2016-12-31 | GSE61429 | GEO
Project description:Chicken Spleen Tissues: MDV-infected vs non-infected in inbred lines 63, 72 & RCSM
| PRJNA130257 | ENA
Project description:Purpose:RNA-seq was uesd to identify how sodium butyrate regulated murine Bregs differentiation. Methods:CD19+ B cells isolated from C57BL/6 mice spleen were were polarized to Bregs differentiation with LPS (10μg/ml) in the absence or presence of sodium butyrate (0.5mM) for 48 hours, and treated with PIM at the last 5 hours following RNA preparation. Results:Using an optimized data analysis workflow, we identified 1462 differentially expressed genes (DEG), of which 720 genes were up-regulated and 742 genes down-regulated, respectively (fold change >2 and adjust p-value < 0.05). RT-qPCR wasused to confirm the reliability of RNA-seq data. KEGG and GSEA analysis indicated that MAPK signaling pathway might involve the function of butyrate on Bregs,which had been proved by western blotting. Using an optimized data analysis workflow, we identified 1462 differentially expressed genes (DEG), of which 720 genes were up-regulated and 742 genes down-regulated, respectively (fold change >2 and adjust p-value < 0.05). RT-qPCR wasused to confirm the reliability of RNA-seq data. KEGG and GSEA analysis indicated that MAPK signaling pathway might involve the function of butyrate on Bregs,which had been proved by western blotting. Using an optimized data analysis workflow, we identified 1462 differentially expressed genes (DEG), of which 720 genes were up-regulated and 742 genes down-regulated, respectively (fold change >2 and adjust p-value < 0.05). RT-qPCR wasused to confirm the reliability of RNA-seq data. KEGG and GSEA analysis indicated that MAPK signaling pathway might involve the function of butyrate on Bregs,which had been proved by western blotting.
2021-06-03 | GSE166021 | GEO
Project description:We analyzed a role of histone deacetylases in alternative splicing regulation. Using human exon arrays we identified a list of 683 genes whose splicing changes after HDAC inhibition with sodium butyrate. 6 samples (3 nontreated controls and 3 sodium butyrate treated cells)
2011-02-03 | E-GEOD-17397 | biostudies-arrayexpress
Project description:Identification of differentially expressed genes in LBH589-treated cells
| PRJNA153461 | ENA