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SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages [ChIP-Seq]

ABSTRACT: SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages [ChIP-Seq]

PROVIDER: PRJNA414045 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6163605.fastq.gz	Fastqsanger.gz
	SRR6163606.fastq.gz	Fastqsanger.gz
	SRR6163607.fastq.gz	Fastqsanger.gz
	SRR7477270.fastq.gz	Fastqsanger.gz
	SRR7477271.fastq.gz	Fastqsanger.gz

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SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages

Project description:SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages

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SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages [Affymetrix]

Project description:SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages [Affymetrix]

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SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages [Affymetrix]

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SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages

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2019-03-12 | GSE114978 | GEO

Gene expression data from human induced pluripotent stem cells and induced pluripotent stem cell-derived human neural progenitor cells

Project description:Embryonic stem cells are pluripotent and possess the ability to differentiate into numerous lineages during the developmental process. In similarity to embryonic stem cells, human induced pluripotent stem cells (iPSCs) possess the potential to differentiate into multiple lineages making them an excellent research tool. We generated iPSCs from multiple donors and also differentiated iPSCs from these donors into human neural progenitor cells (NPCs). We used human transcriptome arrays to detail the programme of gene expression underlying NPC induction and identified distinct classes of up-regulated genes during this process. Total RNAs were extracted from human induced pluripotent stem cells and induced pluripotent stem cell-derived neural progenitor cells. Their gene expression profiles were investigated using the Affymetrix GeneChip Human Transcriptome Array 2.0 platform.

2014-09-12 | E-GEOD-61358 | biostudies-arrayexpress

SALL3 regulates propensity of human induced pluripotent stem cells to differentiate into distinct cell lineages [ChIP-Seq]

Project description:SALL3 binds to de novo DNA methyltransferase DNMT3B and influences the epigenetic profiles of hiPSCs

2019-03-12 | GSE104863 | GEO

Unraveling the Role of MIXL1 Activation in Endoderm Differentiation of Isogenic Human Induced Pluripotent Stem Cells [scRNA-seq]

Project description:Human induced pluripotent stem cells (hiPSC) possess the ability to differentiate into a multitude of tissue types but display heterogeneity in the propensity of differentiation into specific tissue lineages. An examination of isogenic hiPSC lines revealed variations in the endoderm propensity under directed differentiation conditions. Characterization of the transcriptome and proteome of the hiPSC lines showed that MIXL1 activity at the early differentiation stage correlated with the efficacy of generating definitive endoderm and further differentiation into endoderm derivatives. Enforced expression of MIXL1 in the endoderm-incompetent hiPSCs enhanced the propensity of endoderm differentiation, suggesting that modulation of key drivers of lineage differentiation can re-wire hiPSC to the desired lineage propensity for stem cell products.

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Unraveling the Role of MIXL1 Activation in Endoderm Differentiation of Isogenic Human Induced Pluripotent Stem Cells [RNA-Seq]

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Different propensity in hematopoietic differentiation potential among distinct human pluripotent stem cell lines

Project description:Lineage-specific differentiation potential varies among different human pluripotent stem cell (hPSC) lines. A stem cell bank may advice researchers on which hPSCs exhibit the highest differentiation potential for a certain lineage. In this study, we aimed at characterizing the hematopoietic differentiation potential from 14 hESC/iPSC lines through the embryoid body (hEB) differentiation system. We carried out gene expression profiling on six different hESC lines grouped according to their ability to differentiate towards hematopoietic lineage: SHEF1, AND1 and H1 were considered as good (high CD45 expression and high CFU potential), whereas H9, HS181 and VAL3 were selected as poor-blood differentiating lines (low CD45 expression and low CFU potential). Human ESC samples were collected during the exponential cell growth phase and stabilized in RNA later. 500 ng of each total RNA sample was labelled with Cy3 using the Quick-Amp Labelling kit and hybridized with the Gene Expression Hybridization kit to a Whole Human Genome Oligo Microarray (Agilent Technologies) following the Manufacturer’s instructions. Each cell line was analyzed as independent duplicates. H9 hESC line was used as the baseline.

2010-07-24 | E-GEOD-23091 | biostudies-arrayexpress

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