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ABSTRACT: The white adipose tissue is a hub for memory T cells and promotes memory responses

PROVIDER: PRJNA414132 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6166600_1.fastq.gz	Fastqsanger.gz
	SRR6166600_2.fastq.gz	Fastqsanger.gz
	SRR6166601_1.fastq.gz	Fastqsanger.gz
	SRR6166601_2.fastq.gz	Fastqsanger.gz
	SRR6166602_1.fastq.gz	Fastqsanger.gz

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The white adipose tissue is a hub for memory T cells and promotes memory responses

Project description:The white adipose tissue is a hub for memory T cells and promotes memory responses

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The white adipose tissue is a hub for memory T cells and promotes memory responses

Project description:The white adipose tissue represents 15% of healthy mammalian hosts and bridges body organs. In addition to serving as a scaffold for the lymphatic and blood vasculature, this compartment plays a fundamental role in the control of host metabolism. To which extent the adipose tissue also contributes to immune surveillance and long-term protective defense remains largely unknown. Here, we show that under steady state conditions, the white adipose tissue is home to abundant and diverse memory lymphocyte populations. Following infection, the adipose tissue accumulates large numbers of pathogen-specific memory T cells, including tissue-resident (TRM) cells. Memory T cells found in the adipose tissue express a distinct metabolic profile and are characterized by heightened proliferative and effector capacity. As such, adipose tissue from previously infected mice is sufficient to protect from lethal challenge. Local reactivation of adipose tissue memory T cells leads to rapid responses with local impacts on both immune and metabolic pathways, including direct responses by adipocytes. Notably, induction of recall responses within the adipose tissue is associated with the collapse of lipid metabolism in favor of antimicrobial responses. Thus, our results propose that the white adipose tissue, a compartment that interfaces with all body organs, may represent a unique immune compartment, able to provide early warning and potent effector memory responses. Together, these results uncover the adipose tissue as a dominant reservoir of memory T cells endowed with long-term protective functions, positioning this compartment as a potential major contributor of immunological memory.

2017-11-21 | GSE104955 | GEO

Rat white adipose tissue DIGE-LC-MSMS

Project description:White adipose tissue is a central place to energy storage and a major endocrine organ. However, adipose molecular mechanisms have been poorly studied during prolonged fasting. To fill this gap, the aim of this study was to decipher proteomic regulations in rat adipose tissue during phase 2 (lipid mobilization) and phase 3 (protein catabolism) of prolonged fasting compared to the fed state. Specific responses reflecting adipose tissue inflammation, increased fibrinolysis and a possible protein catabolism-related energy saving mechanism were recorded during phase 3. Differences between internal and subcutaneous adipose tissues were essentially related to lipid metabolism, the response to oxidative stress and energy production. These data thus provide a molecular basis of adipose tissue responses according to the fasting stage.

2021-02-24 | PXD010902 | Pride

Obesity expands a distinct population of adipose-resident T cells and increases vulnerability to infection

Project description:Obesity in humans is associated with worsened health outcomes following infections compared to non-obese individuals. Here, we examined the effects of adipose tissue and obesity on T cell responses to virus infection in mice. Lymphocytic choriomeningitis virus (LCMV) grew to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory CD4+ and CD8+ T cells residing in adipose were abundant, accounting for roughly 10% of all virus-specific memory T cells. Diet-induced obesity increased memory T cell number in adipose and spleen. Upon re-challenge infection, memory T cells caused severe pathogenesis, leading to sharply increased lipase levels, calcification of adipose tissue, pancreatitis, and reduced survival in obese mice but not lean mice. Thus, obesity leads to a unique form of viral pathogenesis involving memory T cell-dependent adipocyte destruction and collateral damage to other tissues.

2019-03-19 | GSE110212 | GEO

Expression data from human femur marrow adipose tissue (fMAT) and subcutaneous white adipose tissue of the thigh (tsWAT)

Project description:The bone marrow (BM) is a major reservoir of resting memory T cells and long-lived plasma cells, capable of providing protection against recurrent infections. Whether the age-related accumulation of adipose tissue in the BM affects the functionality and maintenance of memory cells is not well understood. For the first time, we compare human femur marrow adipose tissue (fMAT) and subcutaneous white adipose tissue of the thigh (tsWAT) obtained from the same donors. Using microarrays, we show that fMAT significantly differs from tsWAT regarding specific gene expression profiles including inflammatory responses and adipogenesis. fMAT adipocytes express increased levels of pro-inflammatory molecules concomitant with an elevated generation of reactive oxygen species (ROS) and impaired function of plasma cells in the BM. The reduced expression of adipocyte-specific genes and a less mature adipocyte phenotype in fMAT, relative to tsWAT, suggests that fMAT has more immune regulatory functions. Our findings indicate that fMAT is a unique type of adipose tissue contributing to inflammation and impairment of plasma cell function. We used microarrays to detail the gene expression profil of fMat in comparison to tsWAT in regard to the inflammatory response, adipogenesis/fatty acid metabolism, and redox regulation, and identified distinct classes of up-regulated genes.

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The Gut Microbiota Metabolite Succinate promotes Adipose Tissue Browning in Crohn’s Disease

Project description:In Crohn’s disease (CD), microbe-host interactions are altered, with changes in microbial’s communities and barrier defects leading to translocation of microbes to surrounding adipose tissue (AT). We evaluated the presence of beige AT depots in CD and questioned whether succinate and/or bacterial translocation promotes white-to-beige transition in adipocytes.

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Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories

Project description:This study aimed to identify the genes (including hub genes) and biological pathways that are responsible for the observed changes on subcutaneous and perirenal adipose tissue morphological triats and tissue specific responses to early life malnutrition in a precocial sheep model.

2021-04-17 | GSE166662 | GEO

Impaired adipose-neuronal crosstalk in obesity

Project description:Label-free LC-MS/MS was used to characterise and quantify the secretory profiles of murine perivascular adipose tissue, canonical white adipose tissue, and brown adipose tissue.

2022-11-15 | PXD031271 | Pride

The Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (ChIP-seq, eWAT)

Project description:The goal of this study is to identify the cistrome of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue. Performing Rev-erb alpha ChIP-seq on epididymal white adipose tissue from wildtype mice at 5PM when Rev-erb alpha protein level peaks in wild type (WT) mice, we were able to globally determine the genomic regions undergoing Rev-erb alpha-dependent de-repression. Examination of Rev-erb alpha binding in epididymal white adipose tissue.

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Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism II

Project description:The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tissue. While numerous regulatory factors related to fat deposition have been identified in previous studies, a considerable number of regulatory mechanisms remain unknown. tRNA-derived small RNAs (tsRNAs), a novel class of non-coding RNAs, have emerged as significant regulators in various biological processes. In this study, we obtained small RNA sequencing data from subcutaneous white adipose tissue and omental white adipose tissue of lean and obese pigs. In addition, we similarly obtained tsRNAs profiles from scapular brown adipose tissue (BAT), inguinal white adipose tissue (iWAT) and epigonadal white adipose tissue (eWAT) of normal mice. Finally, we successfully identified a large number of expressed tsRNAs in each tissue type and identified tsRNAs conserved in different adipose tissues of pigs and mice. These datasets will be a valuable resource for elucidating the epigenetic mechanisms of fat deposition.

2023-06-20 | GSE235088 | GEO

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