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Differential gene expression in TREM1 -/- vs +/+ myeloid cells 48h after MCAo-RP

ABSTRACT: Differential gene expression in TREM1 -/- vs +/+ myeloid cells 48h after MCAo-RP

PROVIDER: PRJNA414902 | ENA |

REPOSITORIES: ENA

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Differential gene expression in TREM1 -/- vs +/+ myeloid cells 48h after MCAo-RP

Project description:Stroke is a multiphasic progress characterized by neuron damage due to hypoxia followed by secondary damage from the subsequent inflammatory immune response. Infiltrating myeloid cells induce cerebral damage through pro-inflammatory cytokines, chemokines, proteases and generation of reactive oxygen species (ROS). Triggering receptor expressed on myeloid cells 1 (TREM1) is exclusively expressed on myeloid cells and acts as an amplifier of pro-inflammatory innate immune responses. Using microarray analysis, we aim to identify the expression differences and functional change of these myeloid cells after TREM1 knockout in mice post stroke.

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Expression data from rat (Sprague Dawley) brain subjected to MCAo.

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Expression data from rat (Sprague Dawley) brain subjected to MCAo.

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Project description:In this study we showed that Trem1 is one of genes that were differentially regulated in donor monocytes recovered from non-inflamed and inflamed small intestine of recipient mice. We, therefore, aimed at investigating the role of Trem1 on regulating the monocyte adapatation and differentiation in a context-dependent manner. Thus, the gene expression of WT and Trem1-deficient donor monocytes that are recruited to non-inflamed and inflamed small intestine one day after transfer.

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