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Transcriptional and epigenetic regulation of adaptive NK cell responses [ChIP-Seq]

ABSTRACT: Transcriptional and epigenetic regulation of adaptive NK cell responses [ChIP-Seq]

PROVIDER: PRJNA415720 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6215460_1.fastq.gz	Fastqsanger.gz
	SRR6215460_2.fastq.gz	Fastqsanger.gz
	SRR6215470_1.fastq.gz	Fastqsanger.gz
	SRR6215470_2.fastq.gz	Fastqsanger.gz
	SRR6215461_1.fastq.gz	Fastqsanger.gz

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Transcriptional and epigenetic regulation of adaptive NK cell responses [ChIP-Seq]

Project description:Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Interleukin (IL)-12 signaling through its downstream transcription factor STAT4 is required for the generation of memory NK cells following expansion, while type I interferon through STAT1 is important for NK cell expansion. Here, we identify gene loci that are highly enriched for STAT4 binding using ChIP-seq for STAT4 and the permissive histone mark H3K4me3 in activated NK cells. In addition, we identify gene loci that are high enriched for STAT1 binding in response to type I interferon signaling.

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Project description:Natural killer (NK) cells are circulating lymphocytes that possess both innate and adaptive features, the latter including antigen-specific clonal expansion and long-lived memory responses. Unlike other adaptive lymphocytes like T and B cells, NK cells are not thought to require priming in lymphoid organs during activation. However, although NK cells respond in multiple tissue sites during cytomegalovirus (CMV) infection, here we observed that early activation and virus-specific expansion occurs predominantly in the spleen. These splenic NK cells exhibited heightened TNF-a signaling, which we identify as a novel and critical regulator of both innate and adaptive responses through engagement of distinct NF-kB signaling arms downstream of TNFR2. These findings highlight the central role of the spleen as a lymphoid organ in facilitating the innate-to-adaptive transition NK cells undergo during viral infection, and provide insight into how we can better generate innate and adaptive NK cell immunity across diverse settings. Bulk RNA-Seq data of WT Ly49H+ NK from spleen or liver on day 0 and day 1 post MCMV infection.

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Project description:Tissue-Specific Determinants of Adaptive NK Cell Responses - WT vs TNFR2ko NK

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