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BMAL1-deficiency contributes to mandibular dysplasia by upregulating MMP3

ABSTRACT: BMAL1-deficiency contributes to mandibular dysplasia by upregulating MMP3

PROVIDER: PRJNA417294 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6261605_1.fastq.gz	Fastqsanger.gz
	SRR6261605_2.fastq.gz	Fastqsanger.gz
	SRR6261606_1.fastq.gz	Fastqsanger.gz
	SRR6261606_2.fastq.gz	Fastqsanger.gz
	SRR6261607_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

BMAL1-deficiency contributes to mandibular dysplasia by upregulating MMP3

Project description:Skeletal mandibular hypoplasia (SMH), one of the common types of craniofacial deformities, seriously affects appearance, chewing, pronunciation, and breathing. Moreover, SMH is prone to inducing obstructive sleep apnea syndrome. We found that brain and muscle ARNT-like 1 (BMAL1), the core component of the molecular circadian oscillator, was significantly decreased in mandibles of juvenile SMH patients. Accordingly, SMH was observed in circadian rhythm-disrupted or BMAL1-deficiency mice. RNA sequencing and protein chip analyses suggested that matrix metallopeptidase 3 (MMP3) is the potential target of BMAL1 during the mandibular developmental process. Interestingly, in juvenile SMH patients, we observed that MMP3 level was increased obviously. Consistently, MMP3 was upregulated during the whole growth period of 3 to 10 weeks in Bmal1-/- mice. Given these findings, we set to characterize the underlying mechanism and found that BMAL1-deficiency enhanced Mmp3 transcription through activating p65 phosphorylation. Together our results provide new insight into the mechanism by which BMAL1 is implicated in the pathogenesis of SMH

2017-11-07 | GSE106586 | GEO

BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.

Project description:Skeletal mandibular hypoplasia (SMH), one of the common types of craniofacial deformities, seriously affects appearance, chewing, pronunciation, and breathing. Moreover, SMH is prone to inducing obstructive sleep apnea syndrome. We found that brain and muscle ARNT-like 1 (BMAL1), the core component of the molecular circadian oscillator, was significantly decreased in mandibles of juvenile SMH patients. Accordingly, SMH was observed in circadian-rhythm-disrupted or BMAL1-deficient mice. RNA sequencing and protein chip analyses suggested that matrix metallopeptidase 3 (MMP3) is the potential target of BMAL1. Interestingly, in juvenile SMH patients, we observed that MMP3 was obviously increased. Consistently, MMP3 was upregulated during the whole growth period of 3-10 weeks in Bmal1-/- mice. Given these findings, we set out to characterize the underlying mechanism and found BMAL1 deficiency enhanced Mmp3 transcription through activating p65 phosphorylation. Together, our results provide insight into the mechanism by which BMAL1 is implicated in the pathogenesis of SMH.

| S-EPMC5768965 | biostudies-literature

Expression data from MMP3 and control transgenic mice

Project description:Effect of induction of MMP3 expression in CCSP-rtTA/tet-MMP3 transgenic mice, fed doxycycline for 14 weeks We used microarrays to detail the global programme of gene expression following MMP3 expression Transgenic mice (CCSPrt-TA/tet-MMP3 or CCSPrtTA control mice) were fed doxycycline from week 6 to week 20, then lungs were removed, formalin fixed, and embedded in paraffin. Sections were sliced from the paraffin blocks for RNA extraction.

2010-11-18 | E-GEOD-25439 | biostudies-arrayexpress

MMP3 treatment of Panc-2 cells

Project description:Response of pancreas cancer cells to treatment with recombinant MMP3 Cells were treated with 100U/ml MMP3 for 4 days, then isolated for RNA. The submitted experiments represent two different experiments performed at different times

2014-05-29 | E-GEOD-50931 | biostudies-arrayexpress

MMP3 treatment of SCp2 mouse mammary epithelial cells

Project description:Response of mouse mammary epithelial cells to treatment with MMP3 Cells were untreated (d1 control) or treated with MMP3 for 1-4 days (d1-4 MMP3), or washed and then allowed to recover for three additional days (d5-7 recover) then isolated for RNA.

2014-09-30 | E-GEOD-56909 | biostudies-arrayexpress

Expression data from MMP3 and control transgenic mice

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4T1 vs. MMP3-low 4T1

Project description:Molecular comparison between control 4T1 cells with MMP3-low 4T1 cells

2015-04-22 | GSE68100 | GEO

MMP3 treatment of Panc-2 cells

Project description:Response of pancreas cancer cells to treatment with recombinant MMP3

2014-05-29 | GSE50931 | GEO

Single-cell gene expression of control mandibular bone marrow cells and mandibular bone marrow cells under apical periodontitis

Project description:Single-cell gene expression of mandibular bone marrow cells and mandibular bone marrow cells under the stimulation of apical periodontitis were determined by scRNAseq.

2023-02-11 | GSE212975 | GEO

TMT analysis of proteomic changes in the gastrocnemius skeletal muscles of WT and Bmal1-KO mice, and Bmal1-KO mice rescued with AAV-mediated muscle-specific expression of Bmal1.

Project description:TMT analysis of proteomic changes in the gastrocnemius skeletal muscles of WT and Bmal1-KO mice, and Bmal1-KO mice rescued with AAV-mediated muscle-specific expression of Bmal1.

2024-10-03 | PXD054406 | Pride

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