Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression analysis of control and Ccp6-depleted D3 ESCs

ABSTRACT: Expression analysis of control and Ccp6-depleted D3 ESCs

PROVIDER: PRJNA418120 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression analysis of control and Ccp6-depleted D3 ESCs

Project description:Investigation of differentially expressed genes in Ccp6-depleted D3 ESCs

2017-11-14 | GSE106809 | GEO

Mouse ESCs (ES-D3) with Ash2l depletion

Project description:Mouse ESCs (ES-D3) with Ash2l depletion

| PRJNA563897 | ENA

Genome-wide profiling of genes during differentiation of wild type (WT) murine embryonic stem cells (ESCs), scrambled control (SCR) ESCs and Mageb16-depleted (KD) ESCs

Project description:The Melanoma-associated Antigen gene family (MAGE) generally encodes for tumour antigens. We recently have identified one of the MAGE gene members, Mageb16 to be highly expressed in undifferentiated murine embryonic stem cells (mESCs). The role of Mageb16 for the differentiation of the pluripotent stem cells is completely unknown. Here we demonstrate that Mageb16 (41 kDa) is distributed in cytosol and/or in surface membrane in undifferentiated mESCs. A transcriptome study was performed with differentiated short hairpin RNA (shRNA)-mediated Mageb16 knockdown (KD ESCs) and scrambled control (SCR) ESCs until a period of 22 days. Mageb16 KD ESCs mainly differentiated towards mesodermal derivatives such as cardiovascular lineages. Mesoderm-oriented differentiation initiated biological processes such as adipogenesis, osteogenesis, limb morphogenesis and spermatogenesis were significantly enriched in the differentiated Mageb16 KD ESCs. Cardiomyogenesis in differentiated KD mESCs was stronger when compared to differentiated SCR and wild mESCs. The expression of non-coding RNA (ncRNA) Lin28a and other epigenetic regulatory genes, nucleocytoplasmic trafficking and genes participating in spermatogenesis have also declined faster in the differentiating Mageb16 KD ESCs. We conclude that Mageb16 plays a crucial role for differentiation of ESCs, specifically to the mesodermal lineages. Regulative epigenetic networks and nucleocytoplasmic modifications induced by Mageb16 may play a role for the critical role of Mageb16 for the ESCs differentiation.

2017-09-13 | GSE103615 | GEO

Quantitative Analysis of Transcriptomes between Negative control, UBR5 depleted and MYC depleted HeLa cells

Project description:Quantitative Analysis of Transcriptomes between Negative control, UBR5 depleted and MYC depleted HeLa cells

| PRJNA600869 | ENA

MicroRNA expression in CUL4B-depleted LNCaP cells and control

Project description:MicroRNA expression in CUL4B-depleted LNCaP cells and control

| PRJNA532609 | ENA

Mycobacterium tuberculosis: DNA gyrase depleted Vs control

Project description:Mycobacterium tuberculosis: DNA gyrase depleted Vs control

| PRJNA491719 | ENA

Expression profiling, Lin-9 depletion array in D3 mES cells

Project description:Lin-9 was depleted in ES-D3 cells (ATCC CRL-1934) and the resulting expression profile changes mapped via microarrays

2013-05-13 | E-MTAB-1490 | biostudies-arrayexpress

Quantitative Analysis of Transcriptomes between Negative control, UBR5 depleted and MYC depleted HeLa cells

Project description:Purpose: The goal of this study is to compare the transcriptome changes between Negative control, UBR5 depleted and MYC depleted HeLa cells Methods: Gene expression profiles of Negative control, UBR5 depleted and MYC depleted HeLa cells were generated by deep sequencing, in triplicate. Results:The data were analyzed, and we sucessfully detected global differences in the gene expression between the given groups. Conclusions: UBR5 depletion induces gene expression changes that are partly overlapping with gene expression changes induced by MYC depletion

2020-01-15 | GSE143517 | GEO

RNA-seq analysis of control and MCUR1-depleted HSCs - BioProject

Project description:RNA-seq analysis of control and MCUR1-depleted HSCs - BioProject

| PRJNA718311 | ENA

Expression data from the control and Jmjd1c KD ESCs

Project description:The roles of histone demethylases (HDMs) for the establishment and maintenance of the pluripotent state are incompletely defined. Here, we show that JmjC domain-containing protein 1c (Jmjd1c), a putative histone H3 Lys 9 (H3K9) demethylase, is required for mouse embryonic stem cell (ESC) self-renewal. To understand how Jmjd1c knockdown (KD) and resultant changes in the H3K9 methylations would affect ESCs at a global gene expression level, we compared the whole genome transcriptomes between the control and Jmjd1c KD ESCs (6 samples, including 2 shNT control samples and 4 shJmjd1c samples, 2 from #3 and 2 from #4 shRNA, respectively) using affymetrix microarray. We used microarrays to identify genes affected by Jmjd1c knockdown in mouse ESCs.

2017-07-24 | GSE89709 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data