Dataset Information
Expression profiling, Lin-9 depletion array in D3 mES cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jasmina Esterlechner
PROVIDER: E-MTAB-1490 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells.
PloS one 20130507 5
The DREAM complex plays an important role in regulation of gene expression during the cell cycle. We have previously shown that the DREAM subunit LIN9 is required for early embryonic development and for the maintenance of the inner cell mass in vitro. In this study we examined the effect of knocking down LIN9 on ESCs. We demonstrate that depletion of LIN9 alters the cell cycle distribution of ESCs and results in an accumulation of cells in G2 and M and in an increase of polyploid cells. Genome-w ...[more]
