Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomes of human monocytes after ex vivo exposure to uric acid

ABSTRACT: Transcriptomes of human monocytes after ex vivo exposure to uric acid

PROVIDER: PRJNA421491 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6359080.fastq.gz	Fastqsanger.gz
	SRR6359090.fastq.gz	Fastqsanger.gz
	SRR6359081.fastq.gz	Fastqsanger.gz
	SRR6359091.fastq.gz	Fastqsanger.gz
	SRR6359082.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

Transcriptomes of human monocytes after ex vivo exposure to uric acid

Project description:Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components. In this study we exposed monocytes from healthy donors to uric acid ex vivo, and analyzed the effect of this exposure on gene expression changes. After 'uric acid' or 'media only' treatments, monocytes were exposed to LPS for 4 hours to measure they response to this pyrogen.

2017-12-08 | GSE107821 | GEO

Transcriptomes of human monocytes exposed to oxLDL ex vivo

Project description:Transcriptomes of human monocytes exposed to oxLDL ex vivo

| PRJNA699753 | ENA

Epigenomes and Transcriptomes of human macrophages after ex vivo exposure to mevalonate

Project description:Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components. In this study we exposed monocytes from healthy donors to mevalonate ex vivo, and analyzed the effect of this exposure on gene expression and histone modification changes.

2018-01-08 | GSE104227 | GEO

Uric acid-inducible genes in bacteria from the human gut microbiome

Project description:Approximately 15% of US adults have circulating levels of uric acid above its solubility limit, which is causally linked to the inflammatory disease gout. In most mammals, uric acid elimination is facilitated by the enzyme uricase. However, human uricase is a pseudogene, having been inactivated early in hominid evolution. Though it has long been known that a substantial amount of uric acid is eliminated in the gut, the role of the gut microbiota in hyperuricemia has not been studied. Here we identify a gene cluster, widely distributed in the gut microbiome, that encodes a pathway for uric acid degradation. Stable isotope tracing demonstrates that gut bacteria metabolize uric acid to xanthine or short chain fatty acids such as acetate, lactate and butyrate. Ablation of the microbiota in uricase-deficient mice causes profound hyperuricemia, and anaerobe-targeted antibiotics increase the risk of gout in humans. These data reveal a role for the gut microbiota in uric acid excretion and highlight the potential for microbiome-targeted therapeutics in hyperuricemia.

2023-06-16 | GSE206419 | GEO

RNA Sequencing Facilitates Quantitative Analysis of rat pancreas islet beta cell Transcriptomes in uric acid treat

Project description:The effect of uric acid on islet function remains to be confirmed,We applied GSIS, immunofluorescence staining, WB, and flow cytometry to observe the protective effects of uric acid on beta cell apoptosis and insulin deficiency.To further explore the molecular mechanisms involved in this,we found UA could directly suppressed GSIS in both INS-1E cells and primary isolated islets in a dose- and time-dependent manner. RNAseq suggested that CHOP/NLRP3 is critical in the UA-induced beta cell dysfunction. These data suggest that UA might be an independent risk factor for beta cell function which induced beta cell dysfunction via OAT2/chop/ NLRP3 pathway. which provided new insight into the diabetogenic effect of UA.

2025-02-01 | GSE197089 | GEO

Transcriptomes of human monocytes exposed to oxLDL ex vivo

Project description:Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as Beta glucan or the BCG vaccine. Here we characterize the transcriptional events following oxidized low-density lipoprotein (oxLDL) duced trained innate immunity using RNA-seq data.

2021-10-03 | GSE166238 | GEO

RNAseq analysis of mouse monocytes exposed to IL4 ex vivo

Project description:RNAseq analysis of mouse monocytes exposed to IL4 ex vivo

| PRJNA1117938 | ENA

Gene expression of abnormal uric acid synthesis animal model of silk worm Bombyx mori.

Project description:Uric acid (UA) is the final product of purine metabolism and plays an important role as a physiological antioxidant. In recent years, several different groups have reported a correlation between decreased UA in Parkinson’s disease (PD) and clinical progression and stage of PD. However, little is known about the molecular mechanisms of decreased UA under oxidative stress. We used our systematic functional annotation pipeline for silkworm genes to identify a novel UA metabolic pathway regulator under oxidative stress in a UA metabolism mutant silkworm Bombyx mori model. Gene expression was measured in 3day of fifth instar larvae of abnormal uric acid synthesis Bombyx mori mutant of op.

2013-07-24 | E-GEOD-37735 | biostudies-arrayexpress

The cockroach Blattella germanica obtains nitrogen from uric acid through a metabolic pathway shared with its bacterial endosymbiont

Project description:Uric acid stored in the fat body of cockroaches is a nitrogen reservoir mobilized in times of scarcity. The discovery of urease in Blattabacterium cuenoti, the primary endosymbiont of cockroaches, suggests that the endosymbiont may participate in cockroach nitrogen economy. However, bacterial urease may only be one piece in the entire nitrogen recycling process from insect uric acid. Thus, in addition to the uricolytic pathway to urea, there must be glutamine synthetase assimilating the released ammonia by the urease reaction to enable the stored nitrogen to be metabolically usable. None of the Blattabacterium genomes sequenced to date possess genes encoding for those enzymes. To test the host's contribution to the process, we have sequenced and analysed Blattella germanica transcriptomes from the fat body. We identified transcripts corresponding to all genes necessary for the synthesis of uric acid and its catabolism to urea, as well as for the synthesis of glutamine, asparagine, proline and glycine, i.e. the amino acids required by the endosymbiont. We also explored the changes in gene expression with different dietary protein levels. It appears that the ability to use uric acid as a nitrogen reservoir emerged in cockroaches after its age-old symbiotic association with bacteri

2014-12-08 | E-GEOD-63921 | biostudies-arrayexpress

RNAseq of neutrophils treated with Fungi along with or without uric acid or lactic acid

Project description:To determine the profile of the gene expression changes of neutrophils under the treatment of heatkilled cladosporides with or without lactic acid or uric acid, we conducted the next generation sequencing on the neutrophils isolated from bone marrow cells and treated with fungi for overnight.

2025-04-01 | GSE223080 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data