Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell transcriptomic analysis reveals lineage hierarcies and communications for second heart lineage deployment [RNA-seq]

ABSTRACT: Single-cell transcriptomic analysis reveals lineage hierarcies and communications for second heart lineage deployment [RNA-seq]

PROVIDER: PRJNA428993 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6453440_1.fastq.gz	Fastqsanger.gz
	SRR6453440_2.fastq.gz	Fastqsanger.gz
	SRR6453450_1.fastq.gz	Fastqsanger.gz
	SRR6453450_2.fastq.gz	Fastqsanger.gz
	SRR6453441_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Single-cell transcriptomic analysis reveals lineage hierarcies and communications for second heart lineage deployment

Project description:Single-cell transcriptomic analysis reveals lineage hierarcies and communications for second heart lineage deployment

| PRJNA429249 | ENA

Single-cell transcriptomic analysis reveals lineage hierarcies and communications for second heart lineage deployment [RNA-seq]

Project description:We used single-cell RNA-seq to reconstruct differentiation paths of cardiac progenitors in two sequential waves during early heart development. Further analysis identified six major cell types and multiple differentiation trajectories of cardiac progenitors derived from distinct heart fields. We also constructed TF regulatory networks controlling SHF CPC differentiation. Interlineage crosstalk through signaling pathways and chemotactic guidance played a potent role in SHF CPC deployment. The mechanisms regulating SHF CPC migration and differentiation was further confirmed by Nkx2-5 CPC enhancer knock out. Our work provides a cardiac lineage hierarchy and new insights of SHF CPC development.

2019-06-22 | GSE108879 | GEO

Single-cell transcriptomic analysis reveals lineage hierarcies and communications for second heart lineage deployment

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-06-22 | GSE108963 | GEO

Subpopulations second heart field RNA-seq

Project description:Subpopulations second heart field RNA-seq

| PRJNA509773 | ENA

Subpopulations second heart field ATAC-seq

Project description:Subpopulations second heart field ATAC-seq

| PRJNA509774 | ENA

Heart fields auto-regulate second heart field cell fate via Wnt secretion

Project description:The purpose of this study was to identify the source of Wnt signals that lead to development/proliferation of the heart fields, particularly the second heart field. To this end, we knocked out Wntless (Wls), which is necessary for Wnt secretion, in Mesp1+ lineage cells. We performed single cell RNA-seq to better identify the source of Wnt signals and the effects of the loss of Wnt secretion in mesoderm.

2021-01-23 | GSE165300 | GEO

Subpopulations second heart field RNA-seq

Project description:Transcriptomic profiling of second heart field subpopulations FACS sorted

2020-08-31 | GSE123771 | GEO

Subpopulations second heart field ATAC-seq

Project description:Profiling of open chromatin on second heart field subpopulations FACS sorted

2020-08-18 | GSE123765 | GEO

Hedgehog Molecular Networks in the Second Heart Field

Project description:Hedgehog Molecular Networks in the Second Heart Field

| PRJNA191539 | ENA

Dgcr8 function in the anterior second heart field

Project description:Dgcr8 function in the anterior second heart field