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Microarray data of benzo[a]pyrene-treated WHCO1 vs EPC-2 cells

ABSTRACT: Microarray data of benzo[a]pyrene-treated WHCO1 vs EPC-2 cells

PROVIDER: PRJNA430410 | ENA |

REPOSITORIES: ENA

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Microarray data of benzo[a]pyrene-treated WHCO1 vs EPC-2 cells

Project description:The aim of this project was to investigate the differential effects of benzo[a]pyrene (BaP) treatment on global gene transcription, comparing normal (EPC-2) and cancer (WHCO1) cell lines from the oesophagus, in order to further our understanding of the molecular mechanisms of BaP-induced development and maintenance of oesophageal squamous cell carcinoma.

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Cytochrome P450 Monooxygenase Mediated Metabolic Utilization of Benzo(a)pyrene by Fungi

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Project description:Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male B6C3F1 mice were exposed to four doses of benzo(a)pyrene or vehicle control for three days and sacrificed 4 or 24 hours after the final exposure.

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