Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Microarray data of benzo[a]pyrene-treated WHCO1 vs EPC-2 cells

ABSTRACT: The aim of this project was to investigate the differential effects of benzo[a]pyrene (BaP) treatment on global gene transcription, comparing normal (EPC-2) and cancer (WHCO1) cell lines from the oesophagus, in order to further our understanding of the molecular mechanisms of BaP-induced development and maintenance of oesophageal squamous cell carcinoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109316 | GEO | 2018/01/18

SECONDARY ACCESSION(S): PRJNA430410

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

MicroRNA expression profiling in adult mouse liver following benzo(a)pyrene (BaP) treatment [Agilent miRNA array]

Project description:Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene (BaP), as detected using Agilent miRNA arrays. We have investigated the effect of exposure to 150 mg/kg benzo(a)pyrene (BaP) for 3 days on mRNA and miRNA expression levels in adult mouse liver. We used Agilent miRNA array platforms to assess effects of BaP exposure on miRNA expression levels. Our results indicate a distinct lack of effect of BaP of miRNA expression, despite widespread changes in mRNA levels. Keywords: Toxicology, miRNA

2010-10-18 | GSE18786 | GEO

MicroRNA expression profiling in adult mouse liver following benzo(a)pyrene (BaP) treatment [Exiqon miRNA array]

Project description:Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene (BaP), as detected using Exiqon miRNA arrays. Adult male mice were exposed to 150 mg/kg benzo(a)pyrene (BaP) or solvent for 3 days and sampled 4 hours after the last dose. MicroRNA expression levels in adult mouse liver were measured using Exiqon miRNA arrays. Our results indicate a distinct lack of effect of BaP of miRNA expression, despite widespread changes in mRNA levels (measured using Agilent arrays). Lack of miRNA changes was confirmed with Agilent miRNA arrays. Keywords: Toxicology, miRNA

2010-10-18 | GSE18782 | GEO

Toxicogenomics and phenotypic characterization of adult male zebrafish liver treated with benzo-[A]-pyrene (BAP)

Project description:We performed microarray-based expression profiling on liver of male zebrafish exposed to 5, 50, and 500 µg/L of benzo-[A]-pyrene (BAP) for 24 and 96 hours, to identify global transcriptional programs and biological pathways involved in BAP-induced adaptive responses under in vivo environment.

2012-01-01 | GSE30035 | GEO

HepG2 cells exposed to Benzo[a]pyrene for 6,12,18,24,36 and 48h.

Project description:HepG2 cells (human liver hepatocarcinoma) were exposed for 6 different time points (6,12,18,24,36 and 48h) to Benzo[a]pyrene (BaP) in duplicate.

2015-01-25 | E-MTAB-3251 | biostudies-arrayexpress

Microarray data of benzo[a]pyrene-treated WHCO1 vs EPC-2 cells

Project description:Microarray data of benzo[a]pyrene-treated WHCO1 vs EPC-2 cells

| PRJNA430410 | ENA

Genome-wide maps of DNA methylation in zebrafish larvae through MeDIP-sequencing after benzo[a]pyrene exposure

Project description:In this research, we used MeDIP-sequencing technology to detect genome-wide methylation changes in benzo[a]pyrene(BaP)-exposed zebrafish larvae. We identified differentially methylated genes are associated with many diseases, including development of brain, and central nervous system.This high-throughput sequencing could help us to understand new mechanisms of BaP toxicity.

2016-09-25 | GSE87192 | GEO

Pulmonary gene expression in MutaTMMouse orally gavaged with three doses of benzo(a)pyrene and vehicle control

Project description:In this study, we investigate mRNA profiles in lung of mice exposed to benzo(a)pyrene. Male mice were exposed to three doses (25, 50, and 75 mg/kg/day BaP) for 28 days and profiles were examined three days post-exposure. Our analyses reveal that BaP causes pulmonary specific cellular transformation indicative of carcinogenesis.

2012-10-03 | GSE35718 | GEO

Benzo[a]pyrene and dibenzo[def,p]chrysene in 3D primary human bronchial epithelial cells [miRNA-seq]

Project description:In this study, we assess potential differences in mechanism of action for two PAHs, benzo[a]pyrene (BAP) and dibenzo-[def,p]chrysene (DBC), in a primary human 3D bronchial epithelial culture (HBEC) model based on short-term biosignatures identified from global transcriptional profiling.

2020-03-18 | GSE128492 | GEO

Benzo[a]pyrene and dibenzo[def,p]chrysene in 3D primary human bronchial epithelial cells [RNA-seq]

2020-03-18 | GSE128471 | GEO

Proteomic analysis on the protective effect of eriodictyol on benzo(a)pyrene-induced Caco-2 cytotoxicity

Project description:The present study was aimed to evaluate the protective effects of six different polyphenols against benzo(a)pyrene (BaP)-induced cytotoxicity in Caco-2 cells. The results shows that treatment of quinic acid, ferulic acid, homovanillic acid and BaP decreased the cell viability, whereas only co-treatment of 20 µM eriodictyol and naringenin reduced BaP-induced cytotoxicity, including cell apoptosis, cell cycle change and oxidative stress. Moreover, all results show that the inhibitory effect of eriodictyol was better than that of naringenin. Further, the potential protective mechanism of eriodictyol against BaP-induced toxicity was investigated by proteomics. We found that the genetic information processing pathway involves in 80 differentially expressed proteins (DEPs) showed the highest proportion and number of total proteins. Finally, eriodictyol inhibited BaP-induced cytotoxicity by regulating the expression of key proteins such as RPA2, SNRPA, RAD23B, NUP155 and AARS in transcription and translation. Overall, our results provide a new perspective for polyphenols inhibiting BaP-induced carcinogenesis.

2021-12-17 | PXD030049 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data