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Gene expression in developing fibrotic lesions in tracheas of chlorine-exposed mice

ABSTRACT: Gene expression in developing fibrotic lesions in tracheas of chlorine-exposed mice

PROVIDER: PRJNA430691 | ENA |

REPOSITORIES: ENA

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Gene expression in developing fibrotic lesions in tracheas of chlorine-exposed mice

Project description:Chlorine is a widely used industrial chemical that is also considered a chemical threat agent. Inhalation of chlorine gas can cause acute injury to the respiratory tract, including the death of airway epithelial cells. Failure to efficiently repair the epithelial damage is associated with long-term respiratory abnormalities, including airway fibrosis. We previously developed a model of airway injury in which mice exposed to chlorine gas exhibit epithelial damage and develop fibrosis in large airways. In the present study, we measured gene expression in developing fibrotic lesions isolated from chlorine-exposed mice 4 days after exposure and compared to expression in corresponding areas from unexposed mice. Mesenchymal tissue was isolated by laser-capture microdissection to limit the analysis to the developing fibrotic lesions. The 4-day time point was chosen in an attempt to identify early profibrotic signaling events because at this time fibroblast proliferation has commenced but the fibrotic scar has not yet formed.

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2010-05-06 | E-GEOD-20701 | biostudies-arrayexpress

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Gene expression in 2,3-Pentanedione Induced Bronchiolitis Oblliterans

Project description:Fibrotic and nonfibrotic bronchial tissues were collected from lungs of pentandione exposed rats by laser capture microdissection. Analogous tissue was collected from air-exposed controls. Miroarray analysis revealed a number of DEGs Male Wistar Han rats were exposed to either air or 200 ppm 2,3-pentanedione for 2 wks. Fibrotic bronchial lesions were collected form exposed rats and analogous bronchial tissue was collected from controls. RNA was extracted and amplified to cDNA which was hybridized to Affymetrix microarrays to Rat Gene 1.0 ST Array. Transcript profiles from control and treated rats were compared.

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Characterization of murine non-hematopoietic bone marrow cells in non-fibrotic, pre-fibrotic and fibrotic conditions

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