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Next Generation Sequencing based on the DNA fragment pulled down by p53 antibody (Santa Cruz, sc-126) from MCF7 wile type and MCF7 MDMX-C463A/WT cells.

ABSTRACT: Next Generation Sequencing based on the DNA fragment pulled down by p53 antibody (Santa Cruz, sc-126) from MCF7 wile type and MCF7 MDMX-C463A/WT cells.

PROVIDER: PRJNA431182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6502504_1.fastq.gz	Fastqsanger.gz
	SRR6502504_2.fastq.gz	Fastqsanger.gz
	SRR6502505_1.fastq.gz	Fastqsanger.gz
	SRR6502505_2.fastq.gz	Fastqsanger.gz
	SRR6502506_1.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing based on the DNA fragment pulled down by p53 antibody (Santa Cruz, sc-126) from MCF7 wile type and MCF7 MDMX-C463A/WT cells.

Project description:Hypothesis: Based on gene chip results and further investigation, MDMX C463A/WT cells shows large portion of transcripts change at p53 dependent manner. As transcriptional factor, p53 regulates those genes could be related to DNA binding status change. ChIP-seq was used to test this hypothesis and figure out global map of p53 binding in MCF7 C463A/WT MCF7 cells by using MCF7 parental cells as reference.

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