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Vanillin Ameliorated Azoxymethane/Dextran Sodium Sulfate-Induced Murine Colorectal Cancer: the Involvement of Proteasome/Nuclear factor-κB/Mitogen-Activated Protein Kinase Pathway

ABSTRACT: Vanillin Ameliorated Azoxymethane/Dextran Sodium Sulfate-Induced Murine Colorectal Cancer: the Involvement of Proteasome/Nuclear factor-κB/Mitogen-Activated Protein Kinase Pathway

PROVIDER: PRJNA431462 | ENA |

REPOSITORIES: ENA

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Vanillin Ameliorated Azoxymethane/Dextran Sodium Sulfate-Induced Murine Colorectal Cancer: the Involvement of Proteasome/Nuclear factor-κB/Mitogen-Activated Protein Kinase Pathway

Project description:Vanillin is a natural dietary flavoring. Colorectal cancer (CRC) is one of the common malignancies in the world. Chronic intestinal inflammation is a risk factor for the development of CRC. We have previously found that vanillin improves and prevents the colitis in mice. Here, we evaluated the inhibitory activities of vanillin on a mouse model of colitis-induced colon cancer.

2021-01-15 | GSE109602 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Otud1-/- distal colonic tissue Transcriptomes adjacent to tumors

Project description:Conclusion: Otud1-/- mice are more sensitive to azoxymethane(AOM)-Dextran sulfate (DSS) induced colon tumorigenesis

2020-12-30 | GSE142154 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Otud1-/- distal colonic tumor Transcriptomes

Project description:Conclusion: Otud1-/- mice are more sensitive to azoxymethane(AOM)-Dextran sulfate (DSS) induced colon tumorigenesis

2020-11-12 | GSE140059 | GEO

Azoxymethane induced changes in Rat proximal and distal colonic epithelium.

Project description:Comparison of global gene expression in the proximal and distal colonic epithelium in azoxymethane treated rats. Keywords: disease state analysis

2008-12-05 | GSE13802 | GEO

Acai Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice.

Project description:Background/aimsThe aim of this study was to investigate the protective effect of açaí against azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colorectal cancer development.MethodsThe effect of açaí on tumorigenesis was assessed by evaluating tumor incidence, multiplicity and invasiveness in the mouse colon. The levels of myeloperoxidase (MPO) and proinflammatory cytokines (tumor necrosis factor α [TNF-α], interleukin [IL]-1β, and IL-6) were measured via enzyme-linked immunosorbent assay. Protein levels of cyclooxygenase 2 (COX-2), proliferating cell nuclear antigen (PCNA), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated death promoter (Bad) and cleaved-caspase-3 were assessed by immunoblotting.ResultsAdministration of pellets containing 5% açaí powder reduced the incidences of both colonic adenoma and cancer (adenoma, 23.1% vs 76.9%, respectively, p=0.006; cancer, 15.4% vs 76.9%, respectively, p=0.002). In the açaí-treated mice, the MPO, TNF-α, IL-1β and IL-6 levels in the colon were significantly down-regulated. Açaí inhibited PCNA and Bcl-2 expression and increased Bad and cleaved-caspase-3 expression. In vitro studies demonstrated that açaí treatment reduced lipopolysaccharide-induced expression of TNF-α, IL-1β, IL-6 and COX-2 in murine macrophage RAW 264.7 cells.ConclusionsAçaí demonstrated protective effects against AOM/DSS-induced colon carcinogenesis, which suggests that the intake of açaí may be beneficial for the prevention of human colon cancer.

| S-EPMC5347649 | biostudies-literature

Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway

Project description:Dendritic cell immunoreceptor (DCIR; gene: Clec4a2), a member of the C-type lectin receptor family, plays important roles in homeostasis of the immune and bone systems. However, the intestinal role of this molecule is unclear. Here, we showed that the severity of dextran sodium sulfate (DSS)–induced colitis and the incidence of azoxymethane-DSS–induced intestinal tumors was reduced in Clec4a2–/– mice in an intestinal microbiota–independent manner. STAT5 phosphorylation and expression of Csf2 and tight junction genes were enhanced, while expression of Il17a and Cxcl2 was suppressed in the Clec4a2–/– mouse, which exhibited reduced infiltration of neutrophils and myeloid-derived suppressor cells. GM-CSF administration ameliorated DSS colitis associated with reduced Il17a and enhanced tight junction gene expression, whereas anti–GM-CSF significantly exacerbated the symptoms. Furthermore, blocking the ligand-DCIR interaction ameliorated colitis and prevented colorectal tumors. These observations indicate that blocking DCIR signaling ameliorate colitis and suppresses colonic tumors, suggesting DCIR as a possible target for the treatment of these diseases.

2024-12-01 | GSE190527 | GEO

Effects of dietary folic acid on methylation status of colon non-neoplastic epithelium and dysplasia in mice with colitis

Project description:Folic acid supplementation (8 mg/kg diet) promotes colon tumor formation in mice with established colitis induced by carcinogen azoxymethane (AOM) and dextran sulfate sodium sulfate (DSS). This induction of colon tumors was associated with hypomethylation of DNA cased by folic acid supplementation.

2023-09-07 | GSE168975 | GEO

Effects of dietary folic acid levles on colitis-associated tumorigenesis.

2023-05-31 | GSE168525 | GEO

Mouse colon tumors compared to normal colon

Project description:Label-free proteomics from colon tumors induced in C57BL/6J mice following exposure to azoxymethane plus dextran sodium sulfate. Normal colon was taken from age matched mice not exposed to AOM/DSS.

2024-06-03 | PXD042677 | JPOST Repository

'Mitogen-Induced Defective Mitosis Transforms Neural Progenitor Cells

Project description:'Mitogen-Induced Defective Mitosis Transforms Neural Progenitor Cells

| PRJNA854043 | ENA